Document Detail


Effects of acute psychological stress on adhesion molecules, interleukins and sex hormones: implications for coronary heart disease.
MedLine Citation:
PMID:  12417965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Subjects with high levels of daily stress suffer from an increased risk of coronary heart disease. Increased concentrations of the intercellular adhesion molecule-1 (ICAM-1) contribute to atherosclerosis. Cell adhesion molecules may be activated by psychological stress exposure, depending on their interaction with the interleukin network, sex hormones and cortisol secretion. OBJECTIVES: To assess effects of acute psychological stress on the interaction between cell adhesion molecules, interleukins, sex hormones and cortisol in healthy male subjects. METHODS: Cell adhesion molecules, interleukin-1 beta (IL-1beta), IL-2, IL-6, sex hormones and cortisol levels of 18 healthy male physicians were measured before and after an academic oral presentation and on a control day. RESULTS: The oral presentation was perceived as a stressful event and was accompanied by a significant increase in cortisol secretion in all volunteers. Soluble ICAM-1 and IL-1beta also increased in all subjects after psychological stress exposure. The stress-associated increase in IL-2 concentrations approached statistical significance and correlated negatively with luteinizing hormone plasma levels. Estradiol concentrations correlated positively with IL-6 levels. CONCLUSIONS: Subjective ratings and the increase in cortisol plasma concentrations support the validity of the chosen stress model. Acute stress exposure was followed by an increase in IL-1beta, IL-2 and soluble ICAM-1 plasma concentrations, which can contribute to coronary heart disease and immunological disorders.
Authors:
Andreas Heinz; Derik Hermann; Michael N Smolka; Maike Rieks; Klaus-Jürgen Gräf; Dieter Pöhlau; Wilfried Kuhn; Michael Bauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-11-01
Journal Detail:
Title:  Psychopharmacology     Volume:  165     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-09     Completed Date:  2003-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry of the Charité, Humboldt University of Berlin, Schumannstr. 20/21, 10117 Berlin, Germany. andreas.heinz@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / physiology
Coronary Disease / immunology,  psychology*
Gonadal Steroid Hormones / blood*
Humans
Hydrocortisone / blood*
Intercellular Adhesion Molecule-1 / blood*
Interleukin-1 / blood
Interleukin-2 / blood
Interleukins / blood*
Male
Middle Aged
Risk Factors
Stress, Psychological / complications*
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukins; 126547-89-5/Intercellular Adhesion Molecule-1; 50-23-7/Hydrocortisone

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