Document Detail

Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophrenia.
MedLine Citation:
PMID:  14513924     Owner:  NLM     Status:  MEDLINE    
Although both vasopressin and stress have been implicated in the course of schizophrenia, it is unknown whether schizophrenic patients have altered stress-induced function of the vasopressinergic system. We examined the effects of acute metabolic stress induced by pharmacological doses (40 mg/kg) of 2-deoxyglucose (2DG) on plasma concentrations of vasopressin in 13 patients with schizophrenia (with no history of polydipsia and hyponatremia) and 12 healthy control subjects. Baseline vasopressin levels were lower in the schizophrenic patients and progressively increased in both groups throughout the 60 min following 2DG administration to a similar absolute amount, thus remaining lower in the schizophrenic group. Concomitantly, patients with schizophrenia had significantly higher 2DG-induced plasma homovanillic acid (HVA) and 5-hydroxyindoleacetic acid levels. Vasopressin responses correlated positively and significantly with the HVA responses in schizophrenics and with the pituitary-adrenal axis responses in controls. These results suggest two different patterns of neuroendocrine alterations in schizophrenia, namely a relatively normal vasopressin response to 2DG despite significantly decreased baseline levels and exaggerated responses of the peripheral dopaminegic and serotonergic systems in the face of normal baseline concentrations.
Igor Elman; Scott Lukas; Susan E Shoaf; David Rott; Caleb Adler; Alan Breier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  17     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-29     Completed Date:  2004-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
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MeSH Terms
Adrenocorticotropic Hormone / metabolism
Homovanillic Acid / blood
Hydrocortisone / metabolism
Hydroxyindoleacetic Acid / blood
Schizophrenia / blood*
Serotonin / metabolism
Stress, Physiological / blood,  physiopathology*
Vasopressins / blood,  metabolism*
Reg. No./Substance:
11000-17-2/Vasopressins; 306-08-1/Homovanillic Acid; 50-23-7/Hydrocortisone; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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