Document Detail


Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension.
MedLine Citation:
PMID:  23385649     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: Acute slow breathing (SLOWB) affects sympathetic cardiovascular regulation, but its long-term effects are unknown. Using device-guided breathing we explored short-term and long-term SLOWB effects on blood pressure (BP), heart rate (HR) and muscle sympathetic nerve activity (MSNA) in essential hypertension. METHODS:: We measured BP, HR and MSNA in 10 hypertensive individuals at rest, during laboratory stressors, before and after acute SLOWB, and 8 weeks after SLOWB exercise. Twelve matched hypertensive controls underwent a similar protocol excluding SLOWB intervention. Office and 24-h BP were obtained at baseline and at follow-up. RESULTS:: Acute SLOWB had no influence on BP, HR, but decreased MSNA (P < 0.01). BP, HR, MSNA responses to handgrip were comparable before and after acute SLOWB. Acute SLOWB tended to reduce SBP (P = 0.09), HR (P = 0.08), but not MSNA (P = 0.20) responses to mental stress. Long-term SLOWB decreased office SBP (P < 0.001), DBP (P < 0.01), HR (P = 0.004), but not 24-h BP. Resting MSNA was unchanged after long-term SLOWB (P = 0.68). Long-term SLOWB did not influence BP, HR or MSNA responses to handgrip and cold pressor, but reduced SBP (P = 0.03), HR (P = 0.03) responses to mental stress without MSNA changes. In controls BP, HR, MSNA responses to laboratory stressors remained unchanged at baseline and at follow-up. CONCLUSION:: In essential hypertension, MSNA is reduced during acute SLOWB, but remains unaltered following long-term SLOWB. Long-term SLOWB reduces office, but not ambulatory BP and HR. SLOWB attenuates cardiovascular response to mental stress, but not physical stressors. These findings may be indicative of beneficial SLOWB effects on stress reduction in essential hypertension.
Authors:
Dagmara Hering; Wieslawa Kucharska; Tomas Kara; Virend K Somers; Gianfranco Parati; Krzysztof Narkiewicz
Related Documents :
24226979 - Chemosensory predator recognition in the lizardpodarcis hispanica: effects of predation...
1683249 - Studies with abanoquil (uk-52,046) a novel quinoline alpha 1-adrenoceptor antagonist: i...
2897989 - Desensitization of vascular and platelet alpha 2-adrenoceptors in rabbits with perineph...
6157959 - Effect of clonidine on blood pressure alterations induced in spinal cats.
498699 - Reduced renovascular resistance by clonidine.
1327589 - Do centrally-acting antihypertensive drugs act at non-adrenergic as well as alpha-2 adr...
24269249 - Effectiveness of rosmarinus officinalis essential oil as antihypotensive agent in prima...
19007589 - Acute hemodynamic effects of tolvaptan, a vasopressin v2 receptor blocker, in patients ...
9052899 - Baroreflex impairment by low sodium diet in mild or moderate essential hypertension.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland bICRC, Department of Cardiovascular Diseases, St Anne's University Hospital Brno, Brno, Czech Republic cDivision of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA dDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca eDepartment of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A prospective, randomized, open-label, active-controlled, clinical trial to assess central haemodyna...
Next Document:  Time-of-day of energy intake: association with hypertension and blood pressure 10 years later in the...