| Effects of acute intrathoracic pressure changes on left ventricular geometry and filling. | |
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MedLine Citation:
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PMID: 3041789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute changes in intrathoracic pressure (ITP) affect left ventricular (LV) function. It has been suggested that this functional impairment could be the result of an alteration in LV filling caused by a reduction in LV compliance induced by the rearrangement of biventricular geometry that occurs under these conditions. Therefore, to evaluate the effects of an acute increase or decrease in ITP on LV geometry and filling, we used two-dimensional and Doppler echocardiography to study 25 normal volunteers both during the Müller maneuver (acute decrease in ITP induced by a forced inspiration against a closed airway) and during continuous positive airway pressure breathing. During both maneuvers LV geometry was altered as demonstrated by the significant increase in the normalized curvature radius of the interventricular septum and the unchanged curvature radius of the LV free wall. LV filling was altered during both maneuvers as demonstrated by significant decreases in early peak flow velocity, early-to-late peak flow velocity ratio, and early deceleration rate. Thus, during maneuvers that acutely decrease or increase ITP, alterations in LV geometry occur. These acute distortions of LV geometry may be one of the mechanisms responsible for alterations in LV filling. |
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Authors:
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S Iliceto; M Dambrosio; M Sorino; G D'Ambrosio; A Amico; T Fiore; P Rizzon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 116 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-02 Completed Date: 1988-09-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 455-65 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, University of Bari, Italia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Echocardiography Heart / physiology* Heart Septum / physiology Humans Male Positive-Pressure Respiration Pressure Respiration Thorax / physiology* Ventricular Function |
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