Document Detail

Effects of acute intrathoracic pressure changes on left ventricular geometry and filling.
MedLine Citation:
PMID:  3041789     Owner:  NLM     Status:  MEDLINE    
Acute changes in intrathoracic pressure (ITP) affect left ventricular (LV) function. It has been suggested that this functional impairment could be the result of an alteration in LV filling caused by a reduction in LV compliance induced by the rearrangement of biventricular geometry that occurs under these conditions. Therefore, to evaluate the effects of an acute increase or decrease in ITP on LV geometry and filling, we used two-dimensional and Doppler echocardiography to study 25 normal volunteers both during the Müller maneuver (acute decrease in ITP induced by a forced inspiration against a closed airway) and during continuous positive airway pressure breathing. During both maneuvers LV geometry was altered as demonstrated by the significant increase in the normalized curvature radius of the interventricular septum and the unchanged curvature radius of the LV free wall. LV filling was altered during both maneuvers as demonstrated by significant decreases in early peak flow velocity, early-to-late peak flow velocity ratio, and early deceleration rate. Thus, during maneuvers that acutely decrease or increase ITP, alterations in LV geometry occur. These acute distortions of LV geometry may be one of the mechanisms responsible for alterations in LV filling.
S Iliceto; M Dambrosio; M Sorino; G D'Ambrosio; A Amico; T Fiore; P Rizzon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  116     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-65     Citation Subset:  AIM; IM    
Division of Cardiology, University of Bari, Italia.
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MeSH Terms
Blood Flow Velocity
Heart / physiology*
Heart Septum / physiology
Positive-Pressure Respiration
Thorax / physiology*
Ventricular Function

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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