Document Detail

Effects of acute ingestion of salbutamol during submaximal exercise.
MedLine Citation:
PMID:  11071049     Owner:  NLM     Status:  MEDLINE    
To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80-85% VO2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.
K Collomp; R Candau; R Collomp; J Carra; F Lasne; C Préfaut; J De Ceaurriz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of sports medicine     Volume:  21     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-23     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  480-4     Citation Subset:  IM    
Laboratoire National de Dépistage du Dopage, Chatenay-Malabry, France.
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MeSH Terms
Administration, Oral
Adrenergic beta-Agonists / administration & dosage*
Albuterol / administration & dosage*
Blood Glucose / analysis
C-Peptide / blood
Double-Blind Method
Energy Metabolism / drug effects
Exercise Tolerance / drug effects*
Fatty Acids, Nonesterified / blood
Lactates / blood
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Blood Glucose; 0/C-Peptide; 0/Fatty Acids, Nonesterified; 0/Lactates; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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