Document Detail


Effects of acute incremental volume overload on cardiac chamber size, function, and the pulmonary circulation: analysis by digital intravenous angiography.
MedLine Citation:
PMID:  7102509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effects of acute incremental volume overload on cardiac size, function, and the pulmonary circulation, we studied six anesthetized dogs using intravenous digital angiography. Aortocaval (AC) fistulas were placed in four dogs, and fistulas in both a carotid and iliac artery were placed in two dogs. Data were obtained at four points: (1) control stage; (2) partial shunt (PS, where either AC partially open or iliac fistula was open and carotid fistula was closed); (3) full shunt (FS, AC shunt open or both iliac and carotid shunts open); and (4) control stage 2. Little change in heart rate (HR) or arterial pressure occurred. With FS, both mean pulmonary artery and wedge pressures increased (p less than 0.05); however, systemic and pulmonary vascular resistances declined. Cardiac output rose (1.54 +/- 0.42 L/min at control) to 2.44 +/- 0.84 L/min at PC (P less than 0.05 vs control) and to 3.13 +/- 0.89 L/min at full shunt (p less than 0.01 vs control). Both left (0.40 +/- 0.09 to 0.55 +/- 0.10 to 0.66 +/- 0.10, p less than 0.05 and p less than 0.01 vs control, respectively) and right (0.34 +/- 0.10 to 0.40 +/- 0.10 to 0.51 +/- 0.09, the latter p less than 0.01 vs control) ventricular ejection fractions rose, as did left (30.7 +/- 13 ml to 35.1 +/- 13 ml to 37.8 +/- 13 ml, the latter p less than 0.05 vs control) and right (37.4 +/- 6.1 ml to 44.2 +/- 16.6 ml to 51.4 +/- 17 ml, the latter p less than 0.01 vs control) ventricular end-diastolic volumes. Atrial volume (determined at ventricular end-systole) also increased (9.4 +/- 3.6 ml to 11 +/- 3.5 ml to 12.9 +/- 4.3 ml, the latter p less than 0.05 vs control). These increases in cardiac function and size occurred in association with a shortening of pulmonary transit time (5.4 +/- 0.8 to 3.5 +/- 0.7 seconds to 2.9 +/- 0.5 seconds, the latter two p less than 0.05 and p less than 0.01 vs control, respectively), with no significant change in pulmonary blood volume. We conclude that acute volume overload produces cardiac chamber dilatation, along with increases in systolic function. Both pulmonary and systemic vascular resistance declined, and the transit time in the pulmonary circulation shortened. Digital intravenous ventriculography is a useful technique for the analysis of the central circulation during acute hemodynamic manipulations.
Authors:
R A Slutsky; P H Carey; C B Higgins
Related Documents :
18019 - Effects of increased intracranial pressure on pulmonary vascular resistance of fetal an...
3297489 - Thromboxane synthesis inhibition reverses group b streptococcus-induced pulmonary hyper...
463769 - Differences in hemodynamic effects of nitroprusside and prazosin in severe chronic cong...
436429 - Pulmonary capillary pressure and permeability.
3813189 - Hemodynamic effects of urapidil in patients with pulmonary hypertension. a comparative ...
20504729 - Bronchopulmonary and pressor effects of big-endothelin-1 in the guinea-pig.
935199 - Propranolol and skilled human performance.
12614589 - Noninvasive cerebrovascular autoregulation assessment in traumatic brain injury: valida...
14644719 - A 3-month randomized controlled trial of bimatoprost (lumigan) versus combined timolol ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  104     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-62     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiography
Animals
Aorta / physiopathology,  surgery
Blood Volume*
Blood Volume Determination
Cardiac Volume*
Carotid Arteries / physiopathology,  surgery
Computers
Dogs
Fluoroscopy
Heart / anatomy & histology,  physiopathology*
Hemodynamics*
Heparin / administration & dosage
Iliac Artery / physiopathology,  surgery
Injections, Intravenous
Pulmonary Circulation*
Grant Support
ID/Acronym/Agency:
1K04HL00201/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of the autonomic nervous system on coronary blood flow during partial stenosis.
Next Document:  Postoperative abnormalities of interventricular septal motion: two-dimensional and M-mode echocardio...