Document Detail

Effects of acute hypoxic exposure on prooxidant/antioxidant balance in elite endurance athletes.
MedLine Citation:
PMID:  19177314     Owner:  NLM     Status:  MEDLINE    
We investigated whether acute hypoxic exposures could modify the pro-oxidant/antioxidant balance in elite endurance athletes, known to have efficient antioxidant status. Forty-one elite athletes were subjected to two hypoxic tests: one at an altitude of 4 800 m during 10-min of mild exercise (4 800 m test) and the second at rest for 3 h at an altitude of 3 000 m (3 000 m test). Plasma levels of advanced oxidation protein products (AOPP), malondialdehydes (MDA), ferric reducing antioxidant power (FRAP) and lipid-soluble antioxidants were measured before and immediately after the 4 800 m test and at the end of the 3 000 m test. The 4 800 m and the 3 000 m tests induced a significant increase in the level of MDA and AOPP (+7.1% and +71.7% for 4 800 m test and +8.6% and +40.9% for 3 000 m test). The changes in plasma MDA and arterial oxygen saturations were significantly correlated (r=0.35) during the 3 000 m test. FRAP values (-13%) and alpha-tocopherol (-21%) were decreased following the 3 000 m test. However, following the 4 800 m test, only alpha-tocopherol was decreased (-16%). These results provide evidence that the highly-trained athletes do not have the antioxidant buffering capacity to counterbalance free radical over-production generated by acute hypoxic exposure, with or without mild exercise.
V Pialoux; R Mounier; E Rock; A Mazur; L Schmitt; J-P Richalet; P Robach; J Coudert; N Fellmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-28
Journal Detail:
Title:  International journal of sports medicine     Volume:  30     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Laboratoire de Biologie des Activités Physiques et Sportives, Facultè de Médecine, Clermont-Ferrand, France.
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MeSH Terms
Acute Disease
Analysis of Variance
Anoxia / complications*,  physiopathology
Antioxidants / metabolism*
Biological Markers
Exercise Tolerance*
Free Radical Scavengers / metabolism
Oxidative Stress*
Oxygen Consumption
Reactive Oxygen Species / metabolism*
Young Adult
alpha-Tocopherol / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 59-02-9/alpha-Tocopherol

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