| Effects of acute hypoxemia on responses to dopamine and dobutamine in neonatal swine. | |
| | |
MedLine Citation:
|
PMID: 2072809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of acute hypoxemia on cardiovascular responses to dopamine (DA) and dobutamine (DB) were studied in 2-4 day (n = 21) and 13-17 day (n = 27) old swine under sodium pentobarbital anesthesia. Sequential 10-min infusions of 2, 5 and 15 mu/kg/min of DA or DB or normal saline were administered under conditions of normoxemia and repeated during hypoxemia. Data are presented as mean percent of baseline value +/- SE. During normoxemia, DA increased aortic pressure, cardiac output, heart rate, LV dP/dt max and renal resistance and decreased mesenteric resistance in both ages, while DB increased heart rate, LV dP/dt max and cardiac output in both age groups and decreased total arterial resistance and renal resistance in the youngest. Increases in LV dP/dt max were larger with DA as compared to DB (p less than 0.05) with the highest dose in younger (152 +/- 5% vs. 124 +/- 4%) and older (201 +/- 29% vs. 157 +/- 9%) animals. Hypoxemia reduced heart rate responses to DA and DB in older piglets, contractility responses to DB in older animals, aortic pressure responses to DA in all animals and renal resistance responses to DA in older animals. Hypoxemia had little or no effect on cardiac output and total arterial, mesenteric and carotid resistance responses to DA and DB. Thus, in the newborn: 1) DA is a stronger inotropic agent during normoxemia and hypoxemia while the chronotropic effects of the two drugs did not differ. 2) Changes in cardiac output with both drugs did not differ significantly during normoxemia and were not affected by hypoxemia.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
D B Nudel; B J Peterson; B J Buckley; N Gootman; R G Hoffman |
Related Documents
:
|
7389819 - The effects of alinidine, an n-allyl derivative of clonidine, on regional myocardial pe... 1372729 - Effect on ventricular performance of direct current electrical shock for catheter ablat... 22891519 - Overweight/obesity and hypertension in schoolchildren aged 6-16 years, aden governorate... 8204799 - Effects of magnesium orotate on rat heart function. 22738159 - Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerb... 22710649 - Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than o... 1789939 - Predictors of blood pressure and hypertension. general principles. 9247759 - Blood pressure lowering for the prevention of cognitive decline in patients with cerebr... 12753679 - Systolic hypertension in hemodialysis patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Methods and findings in experimental and clinical pharmacology Volume: 13 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1991-08-22 Completed Date: 1991-08-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: SPAIN |
Other Details:
|
Languages: eng Pagination: 111-9 Citation Subset: IM |
Affiliation:
|
Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aging / physiology Animals Animals, Newborn / physiology Anoxia / physiopathology* Blood Gas Analysis Cardiac Output / drug effects Dobutamine / pharmacology* Dopamine / pharmacology* Heart Rate / drug effects Hemodynamics / drug effects* Hydrogen-Ion Concentration Myocardial Contraction / drug effects Regional Blood Flow / drug effects Swine Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
|
34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On research subsystems and their integration in the computer-supported part of hospital information ...
Next Document: A pharmacokinetic and dynamic study of single nightly doses of conventional and controlled release f...