| Effects of acute hypertension on brain metabolism in normotensive, renovascular hypertensive and spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 675745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of angiotensin-induced acute hypertension on cerebral metabolism were studied in normotensive (NTR), spontaneously hypertensive (SHR) and experimental renovascular hypertensive rats (RHR). Lactate, pyruvate and adenosine triphosphate (ATP) concentrations in the brain frozen in situ at 18--20 min after angiotensin infusion, which raised mean arterial pressure (MAP) by 28--62% of control, were determined by enzymatic methods. Supratentorial lactate was significantly increased to 135% of control in RHR, its increase being correlated with the degree of hypertension, wherease it remained unchanged in NTR or SHR. Furthermore, RHR showed a tendency toward increase in lactate/pyruvate ratio with a decrease in ATP despite no change of arterial acid-base balance measured simultaneously before and after acute induced hypertension. From the present study, it is postulated that some renal factor seems to contribute ischemic metabolic changes in RHR following acute hypertension. The possible effect of renin on the vascular permeability is discussed as the pathogenesis of hypertensive encephalopathy. |
| | |
Authors:
|
M Fujishima; K Onoyama; H Oniki; J Ogata; T Omae |
Related Documents
:
|
8997635 - Recombinant inbred and congenic strains for mapping of genes that are responsible for s... 2309935 - Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats. 16269965 - Castration reduces blood pressure and autonomic venous tone in male spontaneously hyper... 8627985 - Effect of a calcium antagonist on renal hemodynamics in salt-loaded spontaneously hyper... 6829875 - Narcotic antagonism by naloxone. few side-effects after a short procedure? 1708025 - Body sodium in normal subjects predisposed to hypertension. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 9 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1978 Jul-Aug |
Date Detail:
|
Created Date: 1978-09-25 Completed Date: 1978-09-25 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 349-53 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adenosine Triphosphate / metabolism Angiotensin II / pharmacology Animals Blood Pressure / drug effects Brain / metabolism* Glycolysis / drug effects Hypertension / chemically induced, metabolism* Hypertension, Renal / metabolism* Lactates / metabolism Male Pyruvates / metabolism Rats |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 0/Pyruvates; 11128-99-7/Angiotensin II; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A radio-gas chromatographic method for the determination of 11-oxotestosterone in fish plasma: its u...
Next Document: Effect of non-respiratory alkalosis on brain tissue and cerebral blood flow in rats with damaged blo...