Document Detail

Effects of acute hypertension on brain metabolism in normotensive, renovascular hypertensive and spontaneously hypertensive rats.
MedLine Citation:
PMID:  675745     Owner:  NLM     Status:  MEDLINE    
Effects of angiotensin-induced acute hypertension on cerebral metabolism were studied in normotensive (NTR), spontaneously hypertensive (SHR) and experimental renovascular hypertensive rats (RHR). Lactate, pyruvate and adenosine triphosphate (ATP) concentrations in the brain frozen in situ at 18--20 min after angiotensin infusion, which raised mean arterial pressure (MAP) by 28--62% of control, were determined by enzymatic methods. Supratentorial lactate was significantly increased to 135% of control in RHR, its increase being correlated with the degree of hypertension, wherease it remained unchanged in NTR or SHR. Furthermore, RHR showed a tendency toward increase in lactate/pyruvate ratio with a decrease in ATP despite no change of arterial acid-base balance measured simultaneously before and after acute induced hypertension. From the present study, it is postulated that some renal factor seems to contribute ischemic metabolic changes in RHR following acute hypertension. The possible effect of renin on the vascular permeability is discussed as the pathogenesis of hypertensive encephalopathy.
M Fujishima; K Onoyama; H Oniki; J Ogata; T Omae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  9     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1978 Jul-Aug
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Adenosine Triphosphate / metabolism
Angiotensin II / pharmacology
Blood Pressure / drug effects
Brain / metabolism*
Glycolysis / drug effects
Hypertension / chemically induced,  metabolism*
Hypertension, Renal / metabolism*
Lactates / metabolism
Pyruvates / metabolism
Reg. No./Substance:
0/Lactates; 0/Pyruvates; 11128-99-7/Angiotensin II; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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