Document Detail

Effects of acute hemodialysis-induced changes in sodium balance on the renin-angiotensin system in renovascular and spontaneously hypertensive rats.
MedLine Citation:
PMID:  523796     Owner:  NLM     Status:  MEDLINE    
In two-kidney Goldblatt hypertensive, spontaneously hypertensive, and normotensive control rats the activity of the renin-angiotensin system was tested during variation of sodium balance. Acute, exactly calculable and selective changes of total body sodium were achieved by hemodialyzing the conscious rats using dialysate with either high or low sodium content. The activity of the RAS was evaluated by blood pressure response to AT II blockade (saralasin bolus injection; 25 micrograms/kg b.w., i.v.) and the plasma-renin activity. During sodium depletion blood pressure maintenance became renin-dependent; sodium loading caused a decrease of renin-angiotensin activity in renovascular hypertension. A weak direct correlation between deprssor response to saralasin and the PRA could be established in the different sodium-depleted and -loaded states.
A Röckel; A Brand; W Bechinger; A Heidland
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  176     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / antagonists & inhibitors,  blood*
Blood Pressure / drug effects
Hypertension, Renal / blood*
Hypertension, Renovascular / blood*
Rats, Inbred Strains
Renal Dialysis*
Renin / blood*
Saralasin / pharmacology
Sodium / blood*
Time Factors
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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