| Effects of acute fasting and age on leptin and peroxisome proliferator-activated receptor gamma production relative to fat depot in immature and mature pigs. | |
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MedLine Citation:
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PMID: 20455965 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Leptin and peroxisome proliferator-activated receptor gamma (PPARγ) are adipogenic proteins that are actively involved in metabolic homeostasis of fat. Recently, it was reported that fat tissue in humans and rodents differs in metabolic activity relative to anatomical location of the fat tissue (i.e. depots) and animal age. Hence, we hypothesized that leptin and PPARγ production in various fat depots in female pigs differs in response to acute fasting, and that these responses vary with physiological maturity of the animal. Sixteen intact crossbred immature female pigs [prepubertal (PP); 132.2 ± 4.1 days] and 16 sexually mature female pigs (M; 224 ± 7.4 days) housed in an open-air, concrete slab, sheltered barn were randomly assigned to either Control or Fasted treatments. Control pigs (PP, n = 8; M, n = 8) had ad libitum access to feed, while Fasted pigs (PP, n = 8; M, n = 8) were denied access to feed from the onset of the study (0 h) to euthanasia at 72 h. Immediately post-mortem, fat samples were collected from the subcutaneous, pelvic, kidney, and heart (M pigs only) fat depots and analysed for leptin and PPARγ mRNA and protein content. Acute fasting decreased mean leptin mRNA tissue content in a depot specific manner in M pigs (p < 0.01), while mean leptin protein concentrations in fat tissues did not differ with fat depot or age of the pig. Furthermore, acute fasting did not affect mean PPARγ mRNA tissue content in a fat depot or age dependent manner. Mean concentrations of PPARγ protein in fat depots tended to be greater in M vs. PP pigs (p = 0.07). We suggest that these data provide evidence that acute fasting has a greater effect on leptin than PPARγ production in a fat depot dependent manner in M pigs, which may be indicative of changing physiological demands as an animal matures. |
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Authors:
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C W O'Gorman; R L Stanko; D H Keisler; M R Garcia |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of animal physiology and animal nutrition Volume: 94 ISSN: 1439-0396 ISO Abbreviation: J Anim Physiol Anim Nutr (Berl) Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101126979 Medline TA: J Anim Physiol Anim Nutr (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: e266-76 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Verlag GmbH. |
Affiliation:
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Department of Animal & Wildlife Sciences, Dick & Mary Lewis Kleberg College of Agriculture, Natural Resources and Human Sciences, Texas A&M University-Kingsville, Kingsville, TX 78363, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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1P20MD00216-01/MD/NCMHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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