Document Detail


Effects of acute exercise on neutrophils in pediatric acute lymphoblastic leukemia survivors: a pilot study.
MedLine Citation:
PMID:  17023828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This nonrandomized controlled trial was designed to investigate the effects of acute exercise on neutrophil count and function in children and adolescents receiving maintenance treatment for acute lymphoblastic leukemia (ALL) compared to matched controls.
METHODS: Participants (n = 10; 4 ALL patients and 6 healthy matched controls) were males between the ages of 7 to 18 years. On visit 1, participants completed an incremental exercise test to volitional exhaustion on a treadmill to determine peak aerobic fitness (VO(2peak)). On visit 2, participants completed a 30-minute exercise session consisting of an intermittent run-walk on a treadmill at 70% to 85% of VO(2) peak with blood sampling completed at 5 time points: fasting, preexercise, postexercise, 1-hour postexercise, and 2-hour postexercise.
RESULTS: A significant increase in absolute neutrophil count from preexercise to postexercise was observed in both groups (P = 0.011). Neutrophil oxidative capacity was significantly depressed in the ALL group at the basal level (P = 0.029), however, it increased in both groups after exercise and stimulation.
CONCLUSIONS: This preliminary study suggests that 30 minutes of moderate intensity exercise in ALL patients receiving maintenance therapy provides a similar neutrophil response to that of healthy age and sex-matched controls.
Authors:
Aliya B Ladha; Kerry S Courneya; Gordon J Bell; Catherine J Field; Paul Grundy
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  28     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-06     Completed Date:  2007-01-23     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Affiliation:
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Child
Exercise*
Exercise Test
Humans
Leukocyte Count
Male
Neutrophils / metabolism*
Pilot Projects
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*,  therapy
Survivors*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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