| Effects of acute ethanol administration and chronic ethanol feeding on mixed function oxidation in deermice lacking ADH. | |
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MedLine Citation:
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PMID: 3160366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatic microsomes catalyze the oxidation of ethanol and other drugs. The mechanisms through which ethanol alters mixed function oxidation are still debated. There is evidence that ethanol and drugs interact at a microsomal level, but there are also claims that ethanol may interfere with drug metabolism indirectly by affecting the supply of NADPH through NADH production in the ADH pathway. To investigate the role of chronic ethanol consumption, deermice with normal liver ADH (ADH+) or genetically lacking ADH (ADH-) were pair-fed liquid diets containing ethanol or isocaloric carbohydrate for 23 days. The acute effects of ethanol were studied in deermice fed standard laboratory chow and tap water ad lib. In vivo and in vitro, the effects of an acute dose of ethanol and chronic ethanol feeding on mixed function oxidation as measured by the demethylation of aminopyrine were similar in both animal strains. Statistical analysis showed no significant differences between ADH+ and ADH- animals under all experimental conditions studied. We conclude that induction and inhibition of mixed function oxidation by ethanol may be related to the interaction of ethanol with hepatic microsomes rather than to redox changes produced by ADH mediated ethanol metabolism. |
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Authors:
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J Gellert; C S Lieber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 2 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 1985 Jan-Feb |
Date Detail:
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Created Date: 1985-08-27 Completed Date: 1985-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 13-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase Alcohol Oxidoreductases / deficiency*, physiology Aminopyrine / metabolism Animals Dealkylation Ethanol / administration & dosage*, metabolism Microsomes, Liver / drug effects, metabolism Mixed Function Oxygenases / analysis* Oxidation-Reduction Peromyscus |
| Grant Support | |
ID/Acronym/Agency:
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AA 03508/AA/NIAAA NIH HHS; AA 05512/AA/NIAAA NIH HHS; AA 05934/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-15-1/Aminopyrine; 64-17-5/Ethanol; EC 1.-/Mixed Function Oxygenases; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.1/Alcohol Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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