| Effects of acute and chronic starvation on central and peripheral noradrenaline turnover, blood pressure and heart rate in the rat. | |
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MedLine Citation:
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PMID: 10226176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When faced with stress, an organism calls upon several mechanisms to maintain biological homeostasis. The cardiovascular system is the first to respond usually with an increase in arterial pressure and tachycardia. Therefore we investigated the central and peripheral sympathetic responses to acute and chronic starvation in Wistar rats. The noradrenaline (NA) turnover rate was determined in different catecholaminergic nuclei (A1, A2, A5, A6) as well as the arterial blood pressure and heart rate modifications. During acute starvation (3 days of starvation), the NA turnover was increased in the A1 and rostral A2 nuclei as well as in ventricles and kidneys and decreased in the A6 nucleus. During chronic starvation (4 consecutive cycles of 3 days of starvation plus 1 day of feeding), the NA turnover was increased in the A5 and caudal A2 nuclei as well as in ventricles and atria and decreased in the A1 nucleus and kidneys. The arterial blood pressure revealed a gradual decrease during the first 3 days of fasting but the heart rate was not modified. We conclude that starvation should be considered as an unusual state of stress because of the absence of locus coeruleus response (A6 nucleus) despite its well-defined role in stress reactions. One of the manifestations of these central and peripheral noradrenergic changes is the change in blood pressure during the starvation-feeding cycles. |
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Authors:
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S El Fazaa; L Somody; N Gharbi; A Kamoun; C Gharib; G Gauquelin-Koch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental physiology Volume: 84 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-03 Completed Date: 1999-06-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 357-68 Citation Subset: IM; S |
Affiliation:
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Laboratoire de Physiologie Animale, Departement de Biologie, Campus Universitaire, Faculte des Sciences, 1060 Tunis, Tunisia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology* Body Weight / physiology Central Nervous System / metabolism* Drinking Eating Heart Rate / physiology* Hematocrit Kidney / metabolism Male Myocardium / metabolism Norepinephrine / metabolism* Organ Size / physiology Peripheral Nervous System / metabolism* Rats Rats, Wistar Starvation / metabolism*, physiopathology* Sympathetic Nervous System / metabolism*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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