Document Detail

Effects of acute and chronic nicotine on responses maintained by primary and conditioned reinforcers in rats.
MedLine Citation:
PMID:  16893272     Owner:  NLM     Status:  MEDLINE    
There is growing recognition that nonnicotine factors, such as the sensory stimuli associated with smoking, can play a critical role in the maintenance of cigarette smoking. However, little is known about the effects of nicotine on responding maintained by these stimuli, which are assumed to be conditioned reinforcers. The authors used an animal model to examine the acute and chronic effects of nicotine on responses maintained by food and conditioned reinforcers (i.e., lights) and responses in the absence of programmed consequences (i.e., extinction). During the acute phase, 4 male rats received 5 doses of subcutaneous nicotine. One dose of nicotine was then administered for a minimum of 60 days. Food-maintained and extinction responses did not significantly increase during the acute phase; however, food-maintained responses did increase during the chronic phase. Relative to vehicle, intermediate doses increased responses maintained by conditioned reinforcers during both phases. The results suggest that nicotine enhances responding maintained by conditioned reinforcers and possibly by food.
Bethany R Raiff; Jesse Dallery
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  14     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-08     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-305     Citation Subset:  IM    
Department of Psychology, University of Florida, Gainesville, FL 32601, USA.
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MeSH Terms
Conditioning, Classical*
Feeding Behavior / drug effects
Nicotine / administration & dosage*,  pharmacology
Rats, Long-Evans
Reg. No./Substance:

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