Document Detail

Effects of acute and chronic infusion of islet amyloid polypeptide on food intake in rats.
MedLine Citation:
PMID:  8927946     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Islet amyloid polypeptide (IAPP), also called amylin, is a hormonal peptide produced by the islet beta-cells of the pancreas. Because the peptide is co-stored and co-released with insulin, attention has been focused on IAPP's ability to interfere with glucose metabolism. However, IAPP also has other effects, such as a reduction of food intake. METHODS: In this study we investigated the dose-response effect of acute systemic administration of rat and human IAPP on food intake, and the cumulative effect of chronically increased circulating IAPP concentrations on food intake and body weight in the rat. RESULTS: All doses of rat IAPP investigated acutely inhibited food intake. The lowest infusion rate of 8 pmol/kg/min caused an 28% inhibition of the food intake at 2 h (p < 0.05). No effect of human IAPP was observed. Chronic administration of rat IAPP via an osmotic minipump during a 6-day period caused prolonged inhibitory effects on food intake and reduced body weight. During the first 3 days of infusion the food intake of the IAPP group was only 44% of the food intake of the control group (p < 0.001). The body weight of the IAPP group had fallen 18.6 +/- 2.7 g by day 3, in contrast to a small increase in the control group (4.0 +/- 3.1 g; p < 0.001). The reduction in food intake was sustained throughout the last 3 days of study (IAPP, 16.7 +/- 1.1 g/day; control, 20.6 +/- 1.5; p < 0.05). Similarly, the body weight still differed at the end of day 6 and, compared with day 0, was -8.7 +/- 3.7 g for the IAPP group and +10.9 +/- 4.8 for the control group (p < 0.01). CONCLUSIONS: These findings show that chronic increase of circulating IAPP levels can cause a marked reduction in both food intake and body weight and, together with the reduced food intake seen after acute administration of the peptide, indicates the possibility of IAPP functioning as a satiety factor.
U Arnelo; J E Blevins; J Larsson; J Permert; P Westermark; R D Reidelberger; T E Adrian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  31     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-25     Completed Date:  1996-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Dept of Surgery, Linköping University, Sweden.
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MeSH Terms
Amyloid / pharmacology*,  physiology
Body Weight / drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Eating / drug effects*
Infusions, Intravenous
Rats, Sprague-Dawley
Satiety Response / drug effects
Time Factors
Grant Support
Reg. No./Substance:
0/Amyloid; 106602-62-4/amylin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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