Document Detail

Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells.
MedLine Citation:
PMID:  21965748     Owner:  NLM     Status:  In-Data-Review    
MATERIALS AND METHODS: A gastric cancer cell line, OCUM-12, and an esophageal cancer cell line, TE-6, were used. The effects of hypoxia with irradiation on the growth-activity, cell cycle distribution, and gene expression were examined.
RESULTS: Both acute and chronic hypoxia decreased radiosensitivity of cancer cells. The radiosensitivity of chronic hypoxic cells was significantly enhanced by reoxygenation. Acute and chronic all hypoxia reduced the percentage of cells in the G(2)/M and S phases, respectively. In acute hypoxia, the mRNA expression of BRCA1 and BRCA2 was reduced in cancer cells. Reoxygenation increased the expression of BRCA1 and BRCA2.
CONCLUSION: Hypoxia is associated with radiation resistance. Therefore, reoxygenation may enhance the radiosensitivity of hypoxic cells. BRCA1 and BRCA2 may be associated with factors for radiation resistance by regulation of cell cycle progression.
Yukihiro Kato; Masakazu Yashiro; Yuhiko Fuyuhiro; Shinichiro Kashiwagi; Junko Matsuoka; Toshiki Hirakawa; Satoru Noda; Naoki Aomatsu; Tsuyoshi Hasegawa; Taro Matsuzaki; Tetsuji Sawada; Masaichi Ohira; Kosei Hirakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  31     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  3369-75     Citation Subset:  IM    
Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
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