Document Detail

Effects of acute and chronic exercise on sarcolemmal MCT1 and MCT4 contents in human skeletal muscles: current status.
MedLine Citation:
PMID:  22012699     Owner:  NLM     Status:  MEDLINE    
Two lactate/proton cotransporter isoforms (monocarboxylate transporters, MCT1 and MCT4) are present in the plasma (sarcolemmal) membranes of skeletal muscle. Both isoforms are symports and are involved in both muscle pH and lactate regulation. Accordingly, sarcolemmal MCT isoform expression may play an important role in exercise performance. Acute exercise alters human MCT content, within the first 24 h from the onset of exercise. The regulation of MCT protein expression is complex after acute exercise, since there is not a simple concordance between changes in mRNA abundance and protein levels. In general, exercise produces greater increases in MCT1 than in MCT4 content. Chronic exercise also affects MCT1 and MCT4 content, regardless of the initial fitness of subjects. On the basis of cross-sectional studies, intensity would appear to be the most important factor regulating exercise-induced changes in MCT content. Regulation of skeletal muscle MCT1 and MCT4 content by a variety of stimuli inducing an elevation of lactate level (exercise, hypoxia, nutrition, metabolic perturbations) has been demonstrated. Dissociation between the regulation of MCT content and lactate transport activity has been reported in a number of studies, and changes in MCT content are more common in response to contractile activity, whereas changes in lactate transport capacity typically occur in response to changes in metabolic pathways. Muscle MCT expression is involved in, but is not the sole determinant of, muscle H(+) and lactate anion exchange during physical activity.
Claire Thomas; David J Bishop; Karen Lambert; Jacques Mercier; George A Brooks
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-19
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  302     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-03-26     Revised Date:  2012-05-23    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1-14     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale, "Physiologie et Médecine expérimentale du coeur et des muscles", Montpellier, France.
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MeSH Terms
Exercise / physiology*
Hydrogen-Ion Concentration
Lactates / metabolism
Monocarboxylic Acid Transporters / metabolism*
Muscle Proteins / metabolism*
Muscle, Skeletal / metabolism*
Sarcolemma / metabolism*
Symporters / metabolism*
Reg. No./Substance:
0/Lactates; 0/Monocarboxylic Acid Transporters; 0/Muscle Proteins; 0/SLC16A4 protein, human; 0/Symporters; 0/monocarboxylate transport protein 1

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