| Effects of acute changes in blood volume on the carotid sinus baroreceptor reflex in conscious rabbits. | |
| | |
MedLine Citation:
|
PMID: 6875947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The control of blood pressure, heart rate, cardiac output and systemic vascular resistance by the carotid sinus baroreceptor reflex was studied in six conscious rabbits during states of acute hypervolaemia and acute hypovolaemia. These states were produced by infusing blood equal to 20% and 40%, and withdrawing blood equal to 20% and 35%, of the initial blood volume. The properties of the reflex were characterized by creating sinusoidal pressure changes across the wall of the carotid sinus at a frequency of 0.01 Hz and amplitudes of 54 and 83 mmHg. From the effects of the lower-amplitude stimulus the dynamic gain of the reflex was calculated for blood pressure, heart rate, cardiac output and systemic vascular resistance. The higher-amplitude stimulus was used to determine the near maximal responses of the circulatory variables to changes in carotid sinus transmural pressure. The gain for systemic vascular resistance was reduced by hypervolaemia, and increased by 20% hypovolaemia. The gains for heart rate and blood pressure were not affected by hypervolaemia or by 20% hypovolaemia. 35% hypovolaemia reduced the gain for heart rate, but the resting value was close to the upper limit of the reflex response. It also reduced the gain for cardiac output and blood pressure, and the increase in gain for systemic vascular resistance that had been caused by 20% hypovolaemia was not sustained. |
| | |
Authors:
|
I B Faris; G G Jamieson; J Ludbrook |
Related Documents
:
|
3949857 - Advantages of continuous electroencephalographic monitoring during carotid artery surgery. 9887047 - New simple methods for isolating baroreceptor regions of carotid sinus and aortic depre... 22147837 - A longitudinal study of overweight, elevated blood pressure, and acanthosis nigricans a... 2910547 - Importance of aortic baroreflex in regulation of sympathetic responses during hypotensi... 1369707 - The effects of nicardipine in elderly hypertensive patients. 3949857 - Advantages of continuous electroencephalographic monitoring during carotid artery surgery. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of physiology Volume: 337 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1983 Apr |
Date Detail:
|
Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 563-73 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Blood Volume* Cardiac Output Carotid Sinus / physiology* Heart Rate Pressoreceptors / physiology* Rabbits Reflex / physiology* Vascular Resistance |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The relationship between soleus and gastrocnemius muscle activity in conscious cats--a model for mot...
Next Document: Receptive field organization and response properties of spinal neurones with axons ascending the dor...