| Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes. | |
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MedLine Citation:
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PMID: 19628651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of unacylated ghrelin (UAG) and co-administration of acylated ghrelin (AG) and UAG in morbid obesity, a condition characterized by insulin resistance and low GH levels. DESIGN AND METHOD: Eight morbidly obese non-diabetic subjects were treated with either UAG 200 microg, UAG 100 microg in combination with AG 100 microg (Comb) or placebo in three episodes of 4 consecutive days in a double-blind randomized crossover design. Study medication was administered as daily single i.v. bolus injections at 0900 h after an overnight fast. At 1000 h, a standardized meal was served. Glucose, insulin, GH, free fatty acids (FFA) and ghrelin were measured up to 4 h after administration. RESULTS: Insulin concentrations significantly decreased after acute administration of Comb only, reaching a minimum at 20 min: 58.2 + or - 3.9% of baseline versus 88.7 + or - 7.2 and 92.7 + or - 2.6% after administration of placebo and UAG respectively (P<0.01). After 1 h, insulin concentration had returned to baseline. Glucose concentrations did not change after Comb. However, UAG administration alone did not change glucose, insulin, FFA or GH levels. CONCLUSION: Co-administration of AG and UAG as a single i.v. bolus injection causes a significant decrease in insulin concentration in non-diabetic subjects suffering from morbid obesity. Since glucose concentration did not change in the first hour after Comb administration, our data suggest a strong improvement in insulin sensitivity. These findings warrant studies in which UAG with or without AG is administered for a longer period of time. Administration of a single bolus injection of UAG did not influence glucose and insulin metabolism. |
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Authors:
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Rosalie M Kiewiet; Maarten O van Aken; Kim van der Weerd; Piet Uitterlinden; Axel P N Themmen; Leo J Hofland; Yolanda B de Rijke; Patric J D Delhanty; Ezio Ghigo; Thierry Abribat; Aart Jan van der Lely |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-07-23 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 161 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Molinette Hospital, Corso Dogliotti 14, 10126, Turin, Italy. r.kiewiet@erasmusmc.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Adult Blood Glucose / metabolism* Cross-Over Studies Diabetes Mellitus / blood* Double-Blind Method Drug Combinations Fasting / physiology Fatty Acids, Nonesterified / blood Female Ghrelin / adverse effects, analogs & derivatives*, pharmacology* Humans Insulin / blood* Middle Aged Obesity, Morbid / blood* Tachyphylaxis / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Drug Combinations; 0/Fatty Acids, Nonesterified; 0/Ghrelin; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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