Document Detail

Effects of acute administration of acetazolamide and frusemide on lithium clearance in humans.
MedLine Citation:
PMID:  2510078     Owner:  NLM     Status:  MEDLINE    
To investigate the mechanism(s) of acute frusemide-induced increases in FELi, the effects of frusemide and acetazolamide, the carbonic anhydrase inhibiting agent, were evaluated in 19 healthy subjects either before or after pretreatment with acetazolamide or frusemide (11 subjects and eight subjects respectively). Acetazolamide pretreatment did not modify frusemide-induced increases in FELi (delta FLi 12.8 +/- 4.1% compared to 14.6 +/- 7.3%, P = NS); similarly, frusemide pretreatment did not modify acetazolamide-induced increases in FELi (delta FLi: 11.3 +/- 5.9% compared to 9.8 +/- 3.8%, P = NS). Acetazolamide-induced changes of FELi were correlated significantly with acetazolamide-induced increases of FEHCO3 (r = 0.61, P less than 0.05), FENa (r = 0.46, P less than 0.05) but not of FECl (r = 0.25, P = NS). On the other hand, frusemide-induced changes of FELi were correlated significantly with frusemide-induced increases of FENa (r = 0.62, P less than 0.005), FEC1 (r = 0.52, P less than 0.025) but not of FEHCO3 (r = 0.3, P = NS). Thus, frusemide effects on tubular lithium reabsorption are not related to carbonic anhydrase inhibition; furthermore, it appears that frusemide and acetazolamide affect lithium reabsorption by different and independent mechanism(s), possibly acting at different nephron site(s).
G Colussi; G Rombolà; M Surian; M E De Ferrari; C Airaghi; E Benazzi; F Malberti; L Minetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  4     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
Renal Unit, Ospedale Niguarda-Ca Granda, Milan.
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MeSH Terms
Acetazolamide / administration & dosage*,  pharmacokinetics,  urine
Bicarbonates / urine
Drug Administration Schedule
Furosemide / administration & dosage*,  pharmacokinetics,  urine
Glomerular Filtration Rate / drug effects
Infusions, Intravenous
Injections, Intravenous
Kidney Tubules
Kidney Tubules, Distal / drug effects*,  metabolism
Kidney Tubules, Proximal / drug effects*,  metabolism
Lithium / administration & dosage,  pharmacokinetics,  urine*
Lithium Carbonate
Middle Aged
Sodium / urine
Reg. No./Substance:
0/Bicarbonates; 54-31-9/Furosemide; 554-13-2/Lithium Carbonate; 59-66-5/Acetazolamide; 7439-93-2/Lithium; 7440-23-5/Sodium

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