Document Detail

Effects of an active immunization on the immune response of laying Japanese quail (Coturnix coturnix japonica) fed with or without genetically modified Bacillus thuringiensis-maize.
MedLine Citation:
PMID:  20460657     Owner:  NLM     Status:  MEDLINE    
Potentially adverse effects of diets containing transgenic plants are a concern for many consumers, particularly in Europe. For Bacillus thuringiensis-maize, several studies in livestock and poultry showed that the zootechnical data provide no indication for such adverse effects. These studies were all done in homeostatic situations; it remained open whether a deflection of the regulatory physiological systems might yield divergent dynamic responses in B. thuringiensis-maize-fed animals. We therefore tested the effect of an active immunization using BSA as antigen in a feeding regimen with or without B. thuringiensis-maize using quail as a model organism. Newly hatched Japanese quail were randomly allocated to 2 groups (n=120 per group) fed with diets containing either B. thuringiensis-maize or isogenic maize of the same cultivar. The diets did not differ in concentrations of the mycotoxins deoxynivalenol and zearalenone, which were both far below guidance values. After 16 wk on the experimental diets, one-half of each group was immunized against BSA. The remaining birds were injected with saline. Thirty-six hours after the injection, half of the BSA-injected subgroup (n=30) and half of the saline subgroup (n=30) from B. thuringiensis-maize- and isogenic-fed birds were killed and blood samples were collected and analyzed for serum zinc levels, indicative for acute phase response. For determining IgY-mediated immune responses, eggs were collected every other week for 6 wk after the injections from the remaining birds and total IgY concentrations and BSA-specific IgY titers were measured in egg yolk. The BSA injections did not elicit significant decreases of serum zinc concentrations. The serum zinc levels were significantly higher in B. thuringiensis-maize-fed quail. Expectedly, total IgY as well as BSA-specific IgY titers increased with time in the BSA-immunized quail. The response of both variables to the BSA injection did not differ between the feeding groups. Our results indicate that feeding of B. thuringiensis-maize does not impair the immune system of Japanese quail and thus gives no indication for respective concerns.
N D Scholtz; I Halle; S Dänicke; G Hartmann; B Zur; H Sauerwein
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  89     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1122-8     Citation Subset:  IM    
Institute of Animal Science, Physiology and Hygiene Unit, University of Bonn, Katzenburgweg 7-9, 53115, Germany.
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MeSH Terms
Animal Feed
Bacillus thuringiensis / genetics*
Coturnix / immunology*
Oviposition / physiology
Plants, Genetically Modified
Serum Albumin, Bovine / immunology*
Zea mays / genetics*
Reg. No./Substance:
0/Serum Albumin, Bovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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