Document Detail

Effects of acoustic noise on the auditory nerve compound action potentials evoked by electric pulse trains.
MedLine Citation:
PMID:  15811706     Owner:  NLM     Status:  MEDLINE    
This study investigated the effects of acoustic noise on the auditory nerve compound action potentials in response to electric pulse trains. Subjects were adult guinea pigs, implanted with a minimally invasive electrode to preserve acoustic sensitivity. Electrically evoked compound action potentials (ECAP) were recorded from the auditory nerve trunk in response to electric pulse trains both during and after the presentation of acoustic white noise. Simultaneously presented acoustic noise produced a decrease in ECAP amplitude. The effect of the acoustic masker on the electric probe was greatest at the onset of the acoustic stimulus and it was followed by a partial recovery of the ECAP amplitude. Following cessation of the acoustic noise, ECAP amplitude recovered over a period of approximately 100-200 ms. The effects of the acoustic noise were more prominent at lower electric pulse rates (interpulse intervals of 3 ms and higher). At higher pulse rates, the ECAP adaptation to the electric pulse train alone was larger and the acoustic noise, when presented, produced little additional effect. The observed effects of noise on ECAP were the greatest at high electric stimulus levels and, for a particular electric stimulus level, at high acoustic noise levels.
Kirill V Nourski; Paul J Abbas; Charles A Miller; Barbara K Robinson; Fuh-Cherng Jeng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  202     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-07-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-53     Citation Subset:  IM    
Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, 52242, USA.
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MeSH Terms
Action Potentials
Adaptation, Physiological
Cochlear Nerve / physiology*
Electric Stimulation / methods
Electrodes, Implanted
Guinea Pigs
Perceptual Masking
Grant Support

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