Document Detail

Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue of obese subjects.
MedLine Citation:
PMID:  11747144     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acipimox is a hypolipidaemic agent reducing serum concentrations of triglycerides and non-esterified fatty acids. Acipimox may reduce triglyceride synthesis by decreasing non-esterified fatty acid availability from adipocytes, but this effect has yet to be demonstrated in vivo. Lipolysis after acipimox treatment was examined in subcutaneous adipose tissue of severely obese subjects with associated metabolic disorders. METHODS: The microdialysis technique was performed in abdominal subcutaneous adipose tissue of eight hyperinsulinaemic subjects. After oral treatment with acipimox, glycerol concentration was determined as an index of lipolysis rate. Blood flow was assessed by the ethanol escape technique. The rates of release of glycerol from human adipose tissue maximally stimulated by norepinephrine were also investigated in the presence of acipimox. Eight weight- and age-matched subjects served as a control group. RESULTS: Under acipimox treatment, basal glycerol release decreased in subcutaneous adipose tissue, whereas no effect was observed on blood flow. In stimulated adipose tissue acipimox showed no effect. CONCLUSION: In the present study basal glycerol outflow from adipose tissue was inhibited by acipimox. The anti-lipolytic action of the agent may diminish elevated plasma concentrations of free fatty acids in subjects with severe obesity.
M Flechtner-Mors; C P Jenkinson; A Alt; G Adler; H H Ditschuneit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes/metabolism research and reviews     Volume:  17     ISSN:  1520-7552     ISO Abbreviation:  Diabetes Metab. Res. Rev.     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-01-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883450     Medline TA:  Diabetes Metab Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  387-90     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Department of Internal Medicine, University of Ulm, Germany.
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MeSH Terms
Adipose Tissue / blood supply,  drug effects,  metabolism*
Antilipemic Agents / pharmacology*
Blood Flow Velocity
Glycerol / blood
Lipolysis / drug effects*
Middle Aged
Norepinephrine / pharmacology
Obesity / metabolism*
Pyrazines / pharmacology*
Reg. No./Substance:
0/Antilipemic Agents; 0/Pyrazines; 51-41-2/Norepinephrine; 51037-30-0/acipimox; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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