Document Detail

Effects of acid base disturbance, septic shock, and calcium and phosphorous abnormalities on cardiovascular function.
MedLine Citation:
PMID:  3332222     Owner:  NLM     Status:  MEDLINE    
Systemic acidosis has a negative inotropic effect on myocardial function, which in the intact animal, is counteracted by the activation of the sympathoadrenal system. Although there are extensive animal data in this field, human studies quantifying the influence of systemic acidosis on myocardial function in various disease states is lacking. In patients with hypocalcemia, a single infusion of calcium does not sustain increased calcium levels, and the hemodynamic improvement is only transient. Hemodynamic changes in septic shock are complex, and there are convincing data documenting myocardial dysfunction in sepsis. There is a need for elucidating the biochemical characteristics of the myocardial depressant factor (or factors).
P M Mehta; R A Kloner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  3     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-11-22     Completed Date:  1988-11-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-58     Citation Subset:  IM    
Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan.
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MeSH Terms
Acidosis / blood*
Calcium / metabolism*
Myocardial Contraction*
Myocardial Depressant Factor / blood
Phosphates / blood*
Shock, Septic / blood*
Stroke Volume
Vascular Resistance
Reg. No./Substance:
0/Myocardial Depressant Factor; 0/Phosphates; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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