| Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs. | |
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MedLine Citation:
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PMID: 983936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A reproducible model for producing diffuse myocardial injury (epinephrine infusion) has been developed to study the cardioprotective effects of agents or maneuvers which might alter the evolution of acute myocardial infarction. Infusions of epinephrine (4 mug per kilogram per minute for 6 hours) increased radiocalcium uptakes into intact myocardium and each of its subcellular components with the mitochondrial fraction showing the most consistent changes when compared to saline-infused control animals (4,957 vs. 827 counts per minute per gram of dried tissue or fraction). Myocardial concentrations of calcium also increased significantly (12.0 vs. 5.0 mg.per 100 Gm. of fat-free dry weight). Infusions of calcium chloride sufficient to raise serum calcium concentrations 2 mEq. per liter failed to increase calcium influx into the myocardial cell. Mitochondrial radiocalcium uptakes were significantly decreased in animals pretreated with acetylsalicylic acid or dipyridamole or when hydrocortisone was added to the epinephrine infusion (2,682,2,803, and 3,424 counts per minute per gram of dried fraction, respectively). Myocardial calcium concentrations also were decreased (11.2, 8.3, and 8.9 mg. per 100 Gm. of fat-free dry weight, respectively) in the three treatment groups, being significantly decreased only in the last two. Evidence of microscopic damage was graded as less severe in the three treatment groups. Acetylsalicylic acid, dipyridamole, and hydrocortisone all appear to have cardioprotective effects when tested in this model. |
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Authors:
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S Kraikitpanitch; C C Haygood; D J Baxter; A A Yunice; R D Lindeman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 92 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1976-12-30 Completed Date: 1976-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 615-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Aspartate Aminotransferases / blood Aspirin / pharmacology* Calcium / blood Calcium Chloride / adverse effects Cardiomyopathies / chemically induced*, metabolism Dipyridamole / pharmacology* Dogs Drug Therapy, Combination Electrolytes / metabolism Epinephrine / adverse effects* Hydrocortisone / pharmacology* Mitochondria, Muscle / metabolism Myocardial Contraction / drug effects Myocardial Infarction / prevention & control Myocardium / metabolism Necrosis Premedication |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 10043-52-4/Calcium Chloride; 50-23-7/Hydrocortisone; 50-78-2/Aspirin; 51-43-4/Epinephrine; 58-32-2/Dipyridamole; 7440-70-2/Calcium; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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