Document Detail


Effects of the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) on selected endocrine, glucose, and catecholamine levels in fasted and fed rats.
MedLine Citation:
PMID:  3055428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fed and 18-h fasted rats were given acute doses of either saline or the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) 40, 60, or 80 micrograms/kg. After 30 min plasma samples were collected and assayed for glucose, insulin, glucagon, corticosterone, epinephrine and norepinephrine and the hypothalamus was isolated and assayed for acetylcholinesterase activity. Toxic sign scores were determined and they indicated that soman may be more toxic in the fasted rat. Soman-induced increases in corticosterone were observed in both fasted and fed rats; these levels were significantly higher in fasted rats given either soman or saline. Also, soman-induced increases in glucagon were more pronounced in fasted rats. Soman also caused an apparent dose-dependent increase in catecholamines and a decrease in hypothalamic acetylcholinesterase activity in both groups of rats. The expected lower insulin and glucose levels in the fasted rats were present in the saline-dosed animals and remained lower than fed rats after each dose of soman. This lack of soman-induced hyperglycemia may contribute to the toxicity of soman in fasted rats.
Authors:
H P Fletcher; S A Noble; G R Spratto
Related Documents :
12826238 - Dysfunction of aorta involves different patterns of intracellular signaling pathways in...
849278 - The effects of inhibition of gluconeogenesis in suckling newborn rats.
6240478 - Muscle glycogen repletion after exercise in trained normal and diabetic rats.
9571158 - Defect of an early event of glucose metabolism in skeletal muscle of the male otsuka lo...
12695778 - Toxicology and carcinogenesis studies of bromoethane (ethyl bromide) (cas no. 74-96-4) ...
1130218 - Acetylcholine content in the brain and heart of developing rats.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Toxicology     Volume:  52     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Catecholamines / blood*
Cholinesterase Inhibitors / toxicity*
Corticosterone / blood
Fasting
Glucagon / blood
Hormones / blood*
Insulin / blood
Male
Rats
Rats, Inbred Strains
Soman / toxicity*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 0/Cholinesterase Inhibitors; 0/Hormones; 11061-68-0/Insulin; 50-22-6/Corticosterone; 9007-92-5/Glucagon; 96-64-0/Soman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reactive intermediates and their toxicological significance.
Next Document:  Carcinogenic risk assessment in proper perspective.