Document Detail

Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes.
MedLine Citation:
PMID:  17615281     Owner:  NLM     Status:  MEDLINE    
Aerobic exercise capacity is decreased at altitude because of combined decreases in arterial oxygenation and in cardiac output. Hypoxic pulmonary vasoconstriction could limit cardiac output in hypoxia. We tested the hypothesis that acetazolamide could improve exercise capacity at altitude by an increased arterial oxygenation and an inhibition of hypoxic pulmonary vasoconstriction. Resting and exercise pulmonary artery pressure (Ppa) and flow (Q) (Doppler echocardiography) and exercise capacity (cardiopulmonary exercise test) were determined at sea level, 10 days after arrival on the Bolivian altiplano, at Huayna Potosi (4,700 m), and again after the intake of 250 mg acetazolamide vs. a placebo three times a day for 24 h. Acetazolamide and placebo were administered double-blind and in a random sequence. Altitude shifted Ppa/Q plots to higher pressures and decreased maximum O(2) consumption ((.)Vo(2max)). Acetazolamide had no effect on Ppa/Q plots but increased arterial O(2) saturation at rest from 84 +/- 5 to 90 +/- 3% (P < 0.05) and at exercise from 79 +/- 6 to 83 +/- 4% (P < 0.05), and O(2) consumption at the anaerobic threshold (V-slope method) from 21 +/- 5 to 25 +/- 5 ml.min(-1).kg(-1) (P < 0.01). However, acetazolamide did not affect (.)Vo(2max) (from 31 +/- 6 to 29 +/- 7, and the maximum respiratory exchange ratio decreased from 1.2 +/- 0.06 to 1.05 +/- 0.03 (P < 0.001). We conclude that acetazolamide does not affect maximum exercise capacity or pulmonary hemodynamics at high altitudes. Associated changes in the respiratory exchange ratio may be due to altered CO(2) production kinetics.
Vitalie Faoro; Sandrine Huez; Sébastien Giltaire; Adriana Pavelescu; Aurélie van Osta; Jean-Jacques Moraine; Hervé Guenard; Jean-Benoît Martinot; Robert Naeije
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-07-05
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  103     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-05     Completed Date:  2007-12-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1161-5     Citation Subset:  IM    
Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.
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MeSH Terms
Acetazolamide / pharmacology*
Carbonic Anhydrase Inhibitors / pharmacology*
Double-Blind Method
Exercise Tolerance / drug effects*,  physiology
Hemodynamics / drug effects,  physiology
Middle Aged
Oxygen Consumption / drug effects
Pulmonary Circulation / drug effects*,  physiology
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide

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