Document Detail

Effects of acetaminophen and ibuprofen on renal function in the stressed kidney.
MedLine Citation:
PMID:  9931196     Owner:  NLM     Status:  MEDLINE    
Exercise, salt restriction, and/or dehydration causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit young (25 +/- 1 yr) men and women underwent 3 days of a low (10 meq/day)-sodium diet while taking one of the drugs or Pl (crossover design). Day 4 involved dehydration (-1.6% body wt) followed by 45 min of treadmill exercise (65% maximal O2 uptake) in the heat (36 degreesC). These combined stressors caused dramatic decreases in effective renal plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118-123 ml/min) decreased to 78 +/- 4, 73 +/- 5, and 82 +/- 5 ml/min postexercise in the Acet, Ibu, and Pl trials, respectively, with a significantly greater decrease in GFR in the Ibu trial (P < 0. 05 vs. Pl). OTC Ibu has small but statistically significant effects on GFR during exercise in a sodium- and volume-depleted state; OTC Acet was associated with no such effects.
W B Farquhar; A L Morgan; E J Zambraski; W L Kenney
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  86     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  598-604     Citation Subset:  IM    
Noll Physiological Research Center, Pennylvania State University, University Park, Pennsylvania 16802-6900, USA.
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MeSH Terms
Acetaminophen / pharmacology*
Analgesics, Non-Narcotic / pharmacology*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cyclooxygenase Inhibitors / pharmacology*
Dehydration / physiopathology
Diet, Sodium-Restricted
Dinoprostone / biosynthesis,  urine
Exercise Test
Heat Stress Disorders / physiopathology
Ibuprofen / pharmacology*
Kidney / drug effects*,  metabolism,  physiopathology
Kidney Function Tests
Potassium / urine
Renin / blood
Single-Blind Method
Sodium / urine
Stress, Physiological / metabolism,  physiopathology*
Grant Support
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 363-24-6/Dinoprostone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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