| Effects of acebutolol on the serum lipid profile. | |
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MedLine Citation:
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PMID: 3063505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological and recent interventional studies have emphasised the relationship between plasma lipid parameters and the incidence of coronary heart disease. beta-Blockers, particularly those without intrinsic sympathomimetic activity (ISA), are generally reported to increase triglyceride levels and decrease high density lipoprotein (HDL)-cholesterol levels, both changes theoretically increasing the risk of coronary heart disease. A review of all published trials concerning the effects of acebutolol (a cardioselective beta-blocker with mild ISA) on the plasma lipid profile was carried out, with a particular emphasis on studies reporting a comparison with other beta-blockers. The results indicate that, on average, acebutolol does not have any adverse effects on plasma lipids and may even reduce total and low density lipoprotein (LDL)-cholesterol by 7 and 5%, respectively. In contrast, the other beta-blockers compared under the same conditions (propranolol, pindolol and penbutolol) tended to increase triglyceride levels (+19% when compared with acebutolol) and decrease HDL-cholesterol (-7% when compared with acebutolol) to an extent that was consistent with previous reports in the literature. In interpreting these differences in lipid parameters in the light of epidemiological and interventional study data, the use of acebutolol as opposed to the other beta-blockers could theoretically lead to a relative reduction in coronary risk of 20% or more. |
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Authors:
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A Clucas; N Miller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 36 Suppl 2 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1988 |
Date Detail:
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Created Date: 1989-03-06 Completed Date: 1989-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 41-50 Citation Subset: IM |
Affiliation:
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Rhône Poulenc Santé, Antony, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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adverse effects,
pharmacology* Cholesterol / blood* Humans Lipoproteins / blood* Penbutolol / pharmacology Pindolol / pharmacology Propranolol / pharmacology Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Triglycerides; 13523-86-9/Pindolol; 36507-48-9/Penbutolol; 37517-30-9/Acebutolol; 525-66-6/Propranolol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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