Document Detail

Effects of Zinc-l-Carnosine and Vitamin E on Aspirin-Induced Gastroduodenal Injury in Dogs.
MedLine Citation:
PMID:  21092006     Owner:  NLM     Status:  In-Data-Review    
Background: Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-l-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human studies of GI injury. Hypothesis: The combination of zinc-l-carnosine and vitamin E attenuates aspirin-induced gastroduodenal mucosal injury. Animals: Eighteen healthy random-source Foxhound dogs. Methods: In this randomized, double-blinded, placebo-controlled study dogs were treated with placebo (n = 6; 0X group), 30 mg/30 IU (n = 6; 1X group), or 60 mg/60 IU (n = 6; 2X group) zinc-l-carnosine/vitamin E orally every 12 hours for 35 days. Between Day 7 and 35, GI mucosal lesions were induced with aspirin (25 mg/kg PO q8h). Mucosal injury lesions (hemorrhage, erosion, and ulcer) were assessed by gastroduodenoscopy on Days 14, 21, and 35 with a 12-point scoring scale. Results: At baseline (Day -1) gastroscopy scores were not significantly different between groups (mean ± SD: 0X, 4.4 ± 0.8; group 1X, 4.4 ± 0.6; group 2X, 4.2 ± 0.3; P= .55). Gastroscopy scores increased significantly in all groups between Day -1 and Days 14, 21, and 35 (P < .0001). On Day 35, gastroscopy scores were 29.2 ± 5.2 (0X), 27.3 ± 3.7 (1X), and 28.6 ± 3.3 (2X). Mean gastroscopy scores were not significantly different among treatment groups on any of the days (P= .61). Conclusions and Clinical Importance: Administration of the combination of zinc-l-carnosine and vitamin E at 1X or 2X dosing did not attenuate aspirin-induced gastroduodenal mucosal injury.
M Baan; R G Sherding; S E Johnson
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Publication Detail:
Type:  Journal Article     Date:  2010-11-23
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  25     ISSN:  1939-1676     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 by the American College of Veterinary Internal Medicine.
Department of Medical Sciences, School of Veterinary Medicine, The University of Wisconsin-Madison, Madison, WI Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH.
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