Document Detail


Effects of YS-980, an orally active converting enzyme inhibitor, on blood pressure in normotensive and hypertensive rats.
MedLine Citation:
PMID:  6273629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypotensive effect of YS-980, (4R)-3-[(2S)-3-mercapto-2-methyl propanoyl]-4-thiazolidinecarboxylic acid, was investigated in normotensive and different models of hypertensive rats. Experiments were carried out in both anesthetized rats (1 mg/kg i.v.), and conscious unrestrained rats (10 mg/kg p.o.) YS-980 markedly lowered blood pressure in acute renal hypertensive and two-kidney, one-clip hypertensive rats and moderately lowered the pressure in SHR. Contrary to these hypotensive effects, this agent did not reduce the blood pressure in DOCA hypertensive rats. In normotensive rats, YS-980 had a slight hypotensive action in anesthetized rats but not in the conscious animals. The hypotensive effect of YS-980 is attributed mainly to suppression of the renin angiotensin system.
Authors:
T Komori; K Yamamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  31     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  401-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Mercaptopropionic Acid / analogs & derivatives,  pharmacology*
Administration, Oral
Angiotensin-Converting Enzyme Inhibitors*
Animals
Blood Pressure / drug effects*
Desoxycorticosterone / pharmacology
Hypertension / drug therapy,  physiopathology*
Hypertension, Renal / physiopathology
Male
Rats
Rats, Inbred Strains
Sulfhydryl Compounds
Thiazoles / pharmacology*
Thiazolidines
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Sulfhydryl Compounds; 0/Thiazoles; 0/Thiazolidines; 107-96-0/3-Mercaptopropionic Acid; 64-85-7/Desoxycorticosterone; 67714-46-9/(4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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