| The Effects of Weight Loss Versus Weight Loss Maintenance on Sympathetic Nervous System Activity and Metabolic Syndrome Components. | |
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MedLine Citation:
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PMID: 21177786 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Sympathetic nervous system (SNS) overactivity participates in both the pathogenesis and adverse clinical complications of metabolic syndrome (MetS) obesity. Objective: We conducted a prospective lifestyle intervention trial to compare the effects of active weight loss and extended weight loss maintenance on SNS function and MetS components. Methods: Untreated subjects (14 males, four females; mean age, 53 ± 1 yr; body mass index, 30.9 ± 0.9 kg/m(2)) who fulfilled Adult Treatment Panel III criteria were randomized to 12-wk hypocaloric diet alone (n = 8) or together with aerobic exercise training (n = 10). This was followed by a 4-month weight maintenance period. Measurements of muscle sympathetic nerve activity (MSNA) by microneurography, whole-body norepinephrine kinetics, substrate oxidation by indirect calorimetry, baroreflex sensitivity, plasma renin activity (PRA), and MetS components were performed. Results: Body weight decreased by 9.3 ± 0.8% at wk 12 (P < 0.001), and this was maintained. During active weight loss, norepinephrine spillover rate decreased by 23 ± 16% (P = 0.004), MSNA by 25 ± 3 bursts per 100 heartbeats (P < 0.001), and PRA by 0.25 ± 0.09 ng/ml · h (P = 0.007), whereas baroreflex sensitivity increased by 5.2 ± 2.2 msec/mm Hg (P = 0.005). After weight maintenance, beneficial effects of weight loss on norepinephrine spillover rate were preserved, whereas PRA and MSNA rebounded (by 0.24 ± 0.11 ng/ml · h, P = 0.02; and 20 ± 5 bursts/100 heartbeats, P = 0.0003), and baroreflex sensitivity was attenuated. Conclusions: Divergent effects of successful weight loss maintenance on whole-body norepinephrine spillover rate and MSNA suggest organ-specific differentiation in SNS adaptation to weight loss under conditions of negative vs. stable energy balance. |
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Authors:
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Nora E Straznicky; Mariee T Grima; Nina Eikelis; Paul J Nestel; Tye Dawood; Markus P Schlaich; Reena Chopra; Kazuko Masuo; Murray D Esler; Carolina I Sari; Gavin W Lambert; Elisabeth A Lambert |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-22 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratories of Human Neurotransmitters (N.E.S., M.T.G., G.W.L., T.D., R.C., K.M., M.D.E., C.I.S., E.A.L.), Neurovascular Hypertension and Kidney Disease (N.E., M.P.S.), and Cardiovascular Nutrition (P.J.N.), Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia; and Faculty of Medicine, Nursing, and Health Sciences (G.W.L., M.P.S.), and the Department of Physiology (E.A.L., M.D.E.), Monash University, Melbourne, Victoria 3800, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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