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Effects of Weight Loss on Structural and Functional Alterations of Subcutaneous Small Arteries in Obese Patients.
MedLine Citation:
PMID:  21555677     Owner:  NLM     Status:  Publisher    
Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media:lumen ratio, are frequently present in hypertensive and/or diabetic patients and may represent the earliest alteration observed. In addition, media:lumen ratios of small arteries have a strong prognostic significance. However, no data are available about the structure of small resistance arteries of obese patients, particularly after weight loss. We have investigated 27 patients with severe obesity. Twelve of them were normotensive, and 15 were hypertensive. All of the obese patients underwent bariatric surgery. We compared results obtained with those observed in 13 normotensive lean controls and in 13 hypertensive lean patients. All of the subjects and patients underwent a biopsy of subcutaneous fat during surgical intervention. In 8 obese patients, a second biopsy was obtained after consistent weight loss, during a surgical intervention for abdominoplasty. Subcutaneous small resistance arteries were dissected and mounted on a wire myograph, and structural parameters were measured. A concentration-response curve to acetylcholine was performed to evaluate endothelial function. Obese patients, independent from the presence of hypertension, show the presence of an increased media:lumen ratio and media cross-sectional area, together with an impaired endothelial-dependent vasodilatation. After surgical correction of obesity and consistent weight loss, a significant improvement of microvascular structure and of some oxidative stress/inflammation markers were observed. In conclusion, our data suggest that the presence of obesity is associated with structural alterations of subcutaneous small resistance arteries, mainly characterized by hypertrophic remodeling. Weight loss may improve microvascular structure.
Carolina De Ciuceis; Enzo Porteri; Damiano Rizzoni; Claudia Corbellini; Elisa La Boria; Gianluca E M Boari; Annamaria Pilu; Francesco Mittempergher; Ernesto Di Betta; Claudio Casella; Riccardo Nascimbeni; Claudia Agabiti Rosei; Giuseppina Ruggeri; Luigi Caimi; Enrico Agabiti Rosei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Clinica Medica, Department of Medical and Surgical Sciences and the Chair of General Surgery, Department of Medical and Surgical Sciences and the Chair of Clinical Biochemistry, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy.
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