| Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study. | |
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MedLine Citation:
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PMID: 20616787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oral L-citrulline is efficiently converted to L-arginine, the precursor for endothelial nitric oxide (NO) synthesis. Oral L-arginine supplementation reduces brachial blood pressure (BP). We evaluated the effects of watermelon supplementation on aortic BP and arterial function in individuals with prehypertension. METHODS: Heart rate (HR), brachial systolic BP (bSBP), brachial pulse pressure (bPP), aortic SBP (aSBP), aortic PP (aPP), augmentation index (AIx), AIx adjusted for HR of 75 beats/min (AIx@75), amplitude of the first (P1) and second (P2) systolic peaks, reflection time (Tr), and carotid-femoral pulse wave velocity (PWV) were evaluated in the supine position in nine subjects (four men/five women, age 54 ± 3 years) with prehypertension (134/77 ± 5/3 mm Hg). Subjects were randomly assigned to 6 weeks of watermelon supplementation (L-citrulline/L arginine, 2.7 g/1.3 g/day) or placebo followed by a 4-week washout period and then crossover. RESULTS: There was a significant treatment effect (change in the value of watermelon minus placebo from baseline to 6 weeks) on bPP (-8 ± 3 mm Hg, P < 0.05), aSBP (-7 ± 2 mm Hg, P < 0.05), aPP (-6 ± 2 mm Hg, P < 0.01), AIx (-6 ± 3%, P < 0.05), AIx@75 (-4 ± 2%, P < 0.05), and P2 (-2 ± 1 mm Hg, P < 0.05). There was no significant treatment effect (P > 0.05) on bSBP, brachial diastolic BP (DBP), aortic DBP, Tr, P1, HR, and carotid-femoral PWV. CONCLUSIONS: This pilot study shows that watermelon supplementation improves aortic hemodynamics through a decrease in the amplitude of the reflected wave in individuals with prehypertension. |
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Authors:
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Arturo Figueroa; Marcos A Sanchez-Gonzalez; Penelope M Perkins-Veazie; Bahram H Arjmandi |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-07-08 |
Journal Detail:
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Title: American journal of hypertension Volume: 24 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-17 Completed Date: 2011-02-11 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 40-4 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, USA. afiguero@fsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiopathology* Blood Flow Velocity Blood Pressure* Carotid Arteries / physiopathology Citrullus* Cross-Over Studies Double-Blind Method Female Femoral Artery / physiopathology Humans Male Middle Aged Pilot Projects Prehypertension / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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