Document Detail

Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study.
MedLine Citation:
PMID:  20616787     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oral L-citrulline is efficiently converted to L-arginine, the precursor for endothelial nitric oxide (NO) synthesis. Oral L-arginine supplementation reduces brachial blood pressure (BP). We evaluated the effects of watermelon supplementation on aortic BP and arterial function in individuals with prehypertension.
METHODS: Heart rate (HR), brachial systolic BP (bSBP), brachial pulse pressure (bPP), aortic SBP (aSBP), aortic PP (aPP), augmentation index (AIx), AIx adjusted for HR of 75 beats/min (AIx@75), amplitude of the first (P1) and second (P2) systolic peaks, reflection time (Tr), and carotid-femoral pulse wave velocity (PWV) were evaluated in the supine position in nine subjects (four men/five women, age 54 ± 3 years) with prehypertension (134/77 ± 5/3 mm Hg). Subjects were randomly assigned to 6 weeks of watermelon supplementation (L-citrulline/L arginine, 2.7 g/1.3 g/day) or placebo followed by a 4-week washout period and then crossover.
RESULTS: There was a significant treatment effect (change in the value of watermelon minus placebo from baseline to 6 weeks) on bPP (-8 ± 3 mm Hg, P < 0.05), aSBP (-7 ± 2 mm Hg, P < 0.05), aPP (-6 ± 2 mm Hg, P < 0.01), AIx (-6 ± 3%, P < 0.05), AIx@75 (-4 ± 2%, P < 0.05), and P2 (-2 ± 1 mm Hg, P < 0.05). There was no significant treatment effect (P > 0.05) on bSBP, brachial diastolic BP (DBP), aortic DBP, Tr, P1, HR, and carotid-femoral PWV.
CONCLUSIONS: This pilot study shows that watermelon supplementation improves aortic hemodynamics through a decrease in the amplitude of the reflected wave in individuals with prehypertension.
Arturo Figueroa; Marcos A Sanchez-Gonzalez; Penelope M Perkins-Veazie; Bahram H Arjmandi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-07-08
Journal Detail:
Title:  American journal of hypertension     Volume:  24     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  2011-02-11     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, USA.
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MeSH Terms
Aorta / physiopathology*
Blood Flow Velocity
Blood Pressure*
Carotid Arteries / physiopathology
Cross-Over Studies
Double-Blind Method
Femoral Artery / physiopathology
Middle Aged
Pilot Projects
Prehypertension / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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