| Effects of vitamin D supplementation on blood pressure. | |
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MedLine Citation:
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PMID: 20622727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Inconsistent findings from epidemiological studies have continued the controversy over the role of oral vitamin D supplementation in reducing blood pressure in normotensive or hypertensive populations. METHODS: We performed a literature search up to December 2009, with no restrictions. Only double-blind randomized controlled trials (RCTs) of oral vitamin D supplementation in normotensive or hypertensive individuals with blood pressure measurements were included. RESULTS: From 244 retrieved papers, four RCTs involving 429 participants met our inclusion criteria for this meta-analysis. Vitamin D supplementation reduced systolic blood pressure (SBP) by 2.44 mm Hg (weighted mean difference [WMD]: -2.44, 95% confidence interval [CI]: -4.86, -0.02), but not diastolic blood pressure (DBP) (WMD: -0.02, 95% CI: -4.04, 4.01) compared with calcium or placebo. Subgroup analysis suggested that the change of blood pressure did not vary markedly across the dose of vitamin D supplementation, study length, or intervention. CONCLUSIONS: Oral vitamin D supplementation may lead to a reduction in systolic blood pressure but not diastolic blood pressure. Given the small number of trials and small but statistically significant reduction in systolic blood pressure from this meta-analysis, further studies are required to confirm the magnitude of the effect of vitamin D on blood pressure reduction and define the optimum dose, dosing interval, and type of vitamin D to administer. |
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Authors:
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Sheng Hui Wu; Suzanne C Ho; Liu Zhong |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Southern medical journal Volume: 103 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 729-37 Citation Subset: AIM; IM |
Affiliation:
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School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Diastole / drug effects Female Humans Hypertension / drug therapy* Male Middle Aged Randomized Controlled Trials as Topic Systole / drug effects Vitamin D / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
| Comments/Corrections | |
Comment In:
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South Med J. 2010 Aug;103(8):723-4
[PMID:
20622734
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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