Document Detail

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.
MedLine Citation:
PMID:  22995675     Owner:  NLM     Status:  MEDLINE    
Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.
Adam P Chambers; Henriette Kirchner; Hilary E Wilson-Perez; Jill A Willency; John E Hale; Bruce D Gaylinn; Michael O Thorner; Paul T Pfluger; Jesus A Gutierrez; Matthias H Tschöp; Darleen A Sandoval; Randy J Seeley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-17
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-03-04     Revised Date:  2014-10-18    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-52.e5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Body Weight
Dietary Fats
Food Habits*
Ghrelin / blood*,  deficiency,  genetics
Glucose Tolerance Test
Mice, Knockout
Rats, Long-Evans
Signal Transduction
Grant Support
R01 DK076037/DK/NIDDK NIH HHS; R01 DK093848/DK/NIDDK NIH HHS; RC4 DK090956/DK/NIDDK NIH HHS; UL1 TR000077/TR/NCATS NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/Dietary Fats; 0/Ghrelin; 0/ghrelin, des-n-octanoyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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