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Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line.
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MedLine Citation:
PMID:  18472939     Owner:  NLM     Status:  In-Data-Review    
The authors have previously isolated and purified ursolic acid from heather flowers (Calluna vulgarts). This terpene was found to inhibit HL-60 leukaemic cell proliferation and arachidonic acid oxidative metabolism in various cell species. The effects of ursolic acid and its analogues on soybean 15-lipoxygenase activity and on the proliferation of a human gastric tumour cell line (HGT), have been assessed. These triterpenes inhibited soybean 15-lipoxygenase at its optimal activity (pH 9). The proliferation ofHGT was decreased in a dose-dependent manner. At 20 muM the rank order is: ursolic acid > uvaol > oleanolic acid > methyl ursolate. The carboxylic group at the C(28) position of ursolic acid appears to be implicated in the inhibition of both lipoxygenase activity and cell proliferation. Thus methylation of this group decreases these two inhibitory properties. Oleanolic acid, which differs by the position of one methyl group (C(20) instead of C(19)) is less inhibitory than ursolic acid. The lipophilicity of the terpene is also implicated since uvaol appears to be more inhibitory than methyl ursolate.
D Es-Saady; A Najid; A Simon; Y Denizot; A J Chulia; C Delage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  3     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1994  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  -    
Equipe ‘Biomolécules’ Faculté de Pharmacie 2 rue Dr Marcland Limoges 87025 France.
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Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
ISSN: 1466-1861
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 1994 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Year: 1994
Volume: 3 Issue: 3
First Page: 181 Last Page: 184
ID: 2367043
Publisher Item Identifier: S0962935194000244
DOI: 10.1155/S0962935194000244
PubMed Id: 18472939

Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line
D. Es-Saady1
A. Najid2
A. Simon1
Y. Denizot3
A. J. Chulia1
C. Delage1
1Equipe ‘Biomolécules’Faculté de Pharmacie2 rue Dr MarclandLimoges87025France
2Laboratoire Immuno-Hémato-Biochimie (IHB)Pôle Recherche GCAGroupe GuerbetChasse sur Rhône38690France
3Laboratoire d'Hématologie ExpérimentaleFaculté de Médecine2 rue Dr MarclandLimoges87025France

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