Document Detail


Effects of Urate-Lowering Therapy in Hyperuricemia on Slowing the Progression of Renal Function: A Meta-Analysis.
MedLine Citation:
PMID:  23131573     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Uric acid (UA) is generally regarded as an independent risk factor for poor prognosis of patients with kidney disease. However, urate-lowering therapy (ULT) in asymptomatic hyperuricemia is conservative. Whether the beneficial effect on renal function can be achieved by lowering UA remains uncertain. A compound search for randomized controlled trials was conducted in databases consisting of MEDLINE, EMBASE, the Cochrane Library, the Chinese Biomedical Literature Database, and Chinese Science and Technology periodical databases. Two investigators independently screened these studies, assessed the included trials, and extracted data. Eleven articles with a total number of 753 participants met the criteria and were included in our meta-analysis. The results showed that ULT was associated with a decrease in serum creatinine and an increase in eGFR. Our study further confirms that ULT may have beneficial effects on slowing the progression of renal function.
Authors:
Huan Wang; Yong Wei; Xianglei Kong; Dongmei Xu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-3
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  -     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Nephrology, Qianfoshan Hospital, Shandong University, Jinan, People's Republic of China.
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