| Effects of ultra high molecular weight poly-gamma-glutamic acid from Bacillus subtilis (chungkookjang) on corneal wound healing. | |
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MedLine Citation:
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PMID: 20467257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly-gamma-glutamic acid (gamma-PGA) is a natural, edible polypeptide in which glutamate is polymerized via gamma-amide linkages. First, we assessed the eye irritancy potential of gamma PGA in rabbits. Additionally, we studied the effects of gamma-PGA on corneal wound healing, due to the anti inflammatory properties and water retaining abilities of gamma-PGA. In this study, the effects of gamma-PGA on corneal wound healing after an alkali burn were evaluated. Thirty eyes wounded by alkali burning in 30 white rabbits were divided into three groups: group A was treated with 0.1% 5000 kDa gamma-PGA for 2 days, group B was treated with 0.1% hyaluronic acid, and group C was not treated, as a control. The area of corneal epithelial defect was examined at 12, 24, 30, 36, 42, and 48 h after corneal alkali wounding to determine initial wound healing. We found that gamma-PGA promoted corneal wound healing, compared with controls, and showed similar effects to hyaluronic acid. These results indicate that gamma-PGA stimulates corneal wound healing by an anti inflammatory effect and enhancing cell migration and cell proliferation. gamma-PGA is a promising biomaterial that may be a substitute for hyaluronic acid in corneal wound healing treatment. |
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Authors:
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Sun-Ryang Bae; Chung Park; Jae-Chul Choi; Haryoung Poo; Chul-Joong Kim; Moon-Hee Sung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of microbiology and biotechnology Volume: 20 ISSN: 1017-7825 ISO Abbreviation: J. Microbiol. Biotechnol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431852 Medline TA: J Microbiol Biotechnol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 803-8 Citation Subset: IM |
Affiliation:
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College of Medicine, Catholic University, Seoul 150-101, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacillus subtilis / chemistry* Epithelium, Corneal / injuries Histocytochemistry Polyglutamic Acid / analogs & derivatives*, therapeutic use Rabbits Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/poly(gamma-glutamic acid); 25513-46-6/Polyglutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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