Document Detail

Effects of UV-B on the growth pattern of bovine passage I and II lens epithelial cells in vitro.
MedLine Citation:
PMID:  8577464     Owner:  NLM     Status:  MEDLINE    
To further evaluate the pivotal role of epithelial cell proliferation in lens homeostasis, this study compares the principles of regional growth control in central and preequatorial bovine lens epithelial cells in culture. Central lens epithelial cells do not proliferate in vivo while preequatorial cells do. In tissue culture, both central and preequatorial cells proliferate, albeit at different rates. At all stages investigated, nonirradiated passage I central cells proliferated less extensively when compared to the preequatorial cells. In contrast, central passage II cells showed a higher proliferation rate than peripheral cells until day 7, when the situation reversed. UV-B radiation led to a dose-dependent reduction of cell proliferation but did not change the principle cytokinetic differences between central and peripheral cells in passage I cells. Under all circumstances, passage I cells grew more intensively than their passage II counterparts. Data on origin-related differences in cell proliferation of cultured lens epithelial cells suggests growth control features other than just the regionally limited expression of growth factor receptors in the preequatorial extracellular matrix and cell membranes. Investigations are seen as an important step towards a better understanding of the features underlying regional proliferation control and its impairments, at least in lens epithelial cells.
W Breipohl; M Leyendecker; K von Tiesenhausen; F H Grus
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmic research     Volume:  27 Suppl 1     ISSN:  0030-3747     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-14     Completed Date:  1996-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Institut für experimentelle Ophthalmologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
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MeSH Terms
Cell Count
Cell Division / radiation effects
Cells, Cultured
Dose-Response Relationship, Radiation
Epithelial Cells
Epithelium / radiation effects
Lens, Crystalline / cytology,  radiation effects*
Ultraviolet Rays*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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