| Effects of Type II diabetes on muscle microvascular oxygen pressures. | |
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MedLine Citation:
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PMID: 17015044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested the hypothesis that muscle microvascular O2 pressure (PmvO2; reflecting the O2 delivery (QO2) to O2 uptake (VO2) ratio) would be lowered in the spinotrapezius muscle of Goto-Kakizaki (GK) Type II diabetic rats (n=7) at rest and during twitch contractions when compared to control (CON; n=5) rats. At rest, PmvO2 was lower in GK versus CON rats (CON: 29+/-2; GK: 18+/-2Torr; P<0.05). At the onset of contractions, GK rats evidenced a faster change in PmvO2 than CON (i.e., time constant (tau); CON: 16+/-4; GK: 6+/-2s; P<0.05). In contrast to the monoexponential fall in PmvO2 to the steady-state level seen in CON, GK rats exhibited a biphasic PmvO2 response that included a blunted (or non-existent) PmvO2 decrease followed by recovery to a steady-state PmvO2 that was at, or slightly above, resting values. Compared with CON, this decreased PmvO2 across the transition to a higher metabolic rate in Type II diabetes would be expected to impair blood-muscle O2 exchange and contractile function. |
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Authors:
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Danielle J Padilla; Paul McDonough; Brad J Behnke; Yutaka Kano; K Sue Hageman; Timothy I Musch; David C Poole |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-08-26 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 156 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-05-08 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 187-95 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Physiology, 228 Coles Hall, Kansas State University, Manhattan, KS 66506, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Capillaries / metabolism Diabetes Mellitus, Type 2 / blood* Disease Models, Animal Glucose Intolerance / blood* Male Models, Biological Muscle Contraction / physiology Muscle, Skeletal / blood supply, metabolism* Oxygen / blood* Oxygen Consumption / physiology Physical Conditioning, Animal / physiology* Rats Rats, Inbred Strains Rats, Wistar Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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AG-19228/AG/NIA NIH HHS; HL-50306/HL/NHLBI NIH HHS; HL-67619/HL/NHLBI NIH HHS; HL-69739/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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