Document Detail


Effects of type II diabetes on exercising skeletal muscle blood flow in the rat.
MedLine Citation:
PMID:  20798267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present investigation was to examine the muscle hyperemic response to steady-state submaximal running exercise in the Goto-Kakizaki (GK) Type II diabetic rat. Specifically, the hypothesis was tested that Type II diabetes would redistribute exercising blood flow toward less oxidative muscles and muscle portions of the hindlimb. GK diabetic (n = 10) and Wistar control (n = 8, blood glucose concentration, 13.7 ± 1.6 and 5.7 ± 0.2 mM, respectively, P < 0.05) rats were run at 20 m/min on a 10% grade. Blood flows to 28 hindlimb muscles and muscle portions as well as the abdominal organs and kidneys were measured in the steady state of exercise using radiolabeled 15-μm microspheres. Blood flow to the total hindlimb musculature did not differ between GK diabetic and control rats (161 ± 16 and 129 ± 15 ml·min(-1)·100 g(-1), respectively, P = 0.18). Moreover, there was no difference in blood flow between GK diabetic and control rats in 20 of the individual muscles or muscle parts examined. However, in the other eight muscles examined that typically are comprised of a majority of fast-twitch glycolytic (IIb/IIdx) fibers, blood flow was significantly greater (i.e., ↑31-119%, P < 0.05) in the GK diabetic rats. Despite previously documented impairments of several vasodilatory pathways in Type II diabetes these data provide the first demonstration that a reduction of exercising muscle blood flow during submaximal exercise is not an obligatory consequence of this condition in the GK diabetic rat.
Authors:
Steven W Copp; K Sue Hageman; Brad J Behnke; David C Poole; Timothy I Musch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-26
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-02-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1347-53     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, Kansas State University, Manhattan, KS 66506-5802, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Blood Glucose / metabolism
Blood Pressure
Diabetes Mellitus, Type 2 / metabolism,  physiopathology*
Disease Models, Animal
Glycolysis
Heart Rate
Hindlimb
Hyperemia / physiopathology
Male
Muscle Contraction*
Muscle Fibers, Fast-Twitch / metabolism
Muscle Fibers, Slow-Twitch / metabolism
Muscle, Skeletal / blood supply*,  metabolism,  physiopathology*
Oxidation-Reduction
Physical Exertion*
Rats
Rats, Wistar
Regional Blood Flow
Renal Circulation
Splanchnic Circulation
Grant Support
ID/Acronym/Agency:
AG-19228/AG/NIA NIH HHS; HL-50306/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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