Document Detail


The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol.
MedLine Citation:
PMID:  22298226     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the 'Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)' study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400-999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.
Authors:
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-27
Journal Detail:
Title:  Neonatology     Volume:  101     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  301-305     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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Investigator
Investigator/Affiliation:
Axel R Franz / ; Rolf F Maier / ; Ulrich H Thome / ; Mario Ruüdiger / ; Martina Kron / ; Dirk Bassler / ; Christian F Poets / ; Ingeborg Kraägeloh-Mann / ; Mark Schoberer / ; Sonja Trepels-Kottek / ; Gernot Buheitel / ; Wilfried Schenk / ; Christoph Buührer / ; Florian Guthmann / ; Lars Garten / ; Dieter Huüseman / ; Christoph Czernik / ; Rainer Rossi / ; Thomas Kuühn / ; Elisabeth Eilers / ; Norbert Teig / ; Almut Weitkaämper / ; Jes Reinholdt / ; Gitte Veiergang / ; Claudia Roll / ; Wolfgang Pielemeier / ; Violeta Ojinaga / ; Nicole Braun / ; Mario Ruüdiger / ; Hans-Joörg Bittrich / ; Kathrin Roefke / ; Michael Schroth / ; Hans-Georg Topf / ; Anja Stein / ; Matthias Keller / ; Britta-Maria Huüning / ; Doris Fischer / ; Horst Buxmann / ; Matthias Heckmann / ; Dirk Faas / ; Axel von der Wense / ; Peter Gudowius / ; Sarah Kabisch / ; Georg Hillebrand / ; Bettina Bohnhorst / ; Corinna Peter / ; Florian Urlichs / ; Marc Hoppenz / ; Thomas Pabst / ; Angela Kribs / ; Ruth Maria Klein / ; Christoph Huünseler / ; Bernhard Roth / ; Anne Vierzig / ; Frank Eifinger / ; Andreé Oberthuür / ; Kathrin Mehler / ; Ulrich H Thome / ; Corinna Gebauer / ; Matthias Knuüpfer / ; Rolf F Maier / ; Michael Zemlin / ; Larissa Maähnhardt / ; Claudia Franziska Nussbaum / ; Alexandra Schwepcke / ; Georg Rellensmann / ; Esther Rieger-Fackeldey / ; Jan-Holger Schiffmann / ; Jens Grombach / ; Stefan Schaäfer / ; Hugo Segerer / ; Annette Keller-Wackerbauer / ; Rainer Burghard / ; Mechthild Hubert / ; Matthias Vochem / ; Ulrich Pohlmann / ; Patrick Neuberger / ; Martin Wagner / ; Axel Franz / ; Dirk Bassler / ; Hans Fuchs / ; Manuel Schmid / ; Reinhard Hopfner / ; Hans Ulrich Bucher / ; Heike Rabe / ; Josef Hoögel / ; Corinna Engel / ; Joachim Riethmuüller /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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