| Effects of Topiramate on Dysaesthetic Pain in a Patient with Multiple Sclerosis. | |
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MedLine Citation:
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PMID: 23288696 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe the case of a 42-year-old woman with an 8-year history of multiple sclerosis who developed dysaesthetic pain in the lower limbs, and was successfully treated with topiramate at a final dose of 150 mg/day. About 8 months after beginning topiramate treatment, the patient had not shown any dysaesthetic pain, and no adverse events related to topiramate had been recorded. |
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Authors:
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Antonio Siniscalchi; Luca Gallelli; Giovambattista De Sarro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-4 |
Journal Detail:
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Title: Clinical drug investigation Volume: - ISSN: 1179-1918 ISO Abbreviation: Clin Drug Investig Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neuroscience, Neurology Division, "Annunziata" Hospital, Cosenza, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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