Document Detail


Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis.
MedLine Citation:
PMID:  23288696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe the case of a 42-year-old woman with an 8-year history of multiple sclerosis who developed dysaesthetic pain in the lower limbs, and was successfully treated with topiramate at a final dose of 150 mg/day. About 8 months after beginning topiramate treatment, the patient had not shown any dysaesthetic pain, and no adverse events related to topiramate had been recorded.
Authors:
Antonio Siniscalchi; Luca Gallelli; Giovambattista De Sarro
Related Documents :
25415786 - Pulsed radiofrequency for occipital neuralgia.
2610236 - Stapes surgery in osteogenesis imperfecta.
25293476 - Sympathetic nerve blocks for the management of postherpetic neuralgia - 19 years of pai...
25353156 - Effectiveness of diathermy in comparison with ultrasound or corticosteroids in patients...
11324796 - Emg activity and pain development in fibromyalgia patients exposed to mental stress of ...
21684216 - Overexpression of gdnf in the uninjured drg exerts analgesic effects on neuropathic pai...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical drug investigation     Volume:  33     ISSN:  1179-1918     ISO Abbreviation:  Clin Drug Investig     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-07-22     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  9504817     Medline TA:  Clin Drug Investig     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / adverse effects,  therapeutic use*
Female
Fructose / adverse effects,  analogs & derivatives*,  therapeutic use
Humans
Lower Extremity
Multiple Sclerosis / drug therapy*,  physiopathology
Neuralgia / drug therapy*,  etiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improving Treatment Adherence in Your Patients with Schizophrenia : The STAY Initiative.
Next Document:  A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria.