Document Detail

Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis.
MedLine Citation:
PMID:  23288696     Owner:  NLM     Status:  MEDLINE    
Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe the case of a 42-year-old woman with an 8-year history of multiple sclerosis who developed dysaesthetic pain in the lower limbs, and was successfully treated with topiramate at a final dose of 150 mg/day. About 8 months after beginning topiramate treatment, the patient had not shown any dysaesthetic pain, and no adverse events related to topiramate had been recorded.
Antonio Siniscalchi; Luca Gallelli; Giovambattista De Sarro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical drug investigation     Volume:  33     ISSN:  1179-1918     ISO Abbreviation:  Clin Drug Investig     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-07-22     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  9504817     Medline TA:  Clin Drug Investig     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy.
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use*
Fructose / adverse effects,  analogs & derivatives*,  therapeutic use
Lower Extremity
Multiple Sclerosis / drug therapy*,  physiopathology
Neuralgia / drug therapy*,  etiology
Treatment Outcome
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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