| Effects of topical corticosteroid and tacrolimus on ceramides and irritancy to sodium lauryl sulphate in healthy skin. | |
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MedLine Citation:
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PMID: 21365172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The skin barrier, located in the stratum corneum, is influenced mainly by the lipid and protein composition of this layer. In eczematous diseases impairment of the skin barrier is thought to be of prime importance. Topical anti-inflammatory drugs and emollients are the most widely used eczema treatments. The aim of this study was to examine the effects of topically applied corticosteroid, tacrolimus and emollient on stratum corneum lipids and barrier parameters. Nineteen healthy volunteers participated in the study. Both forearms of the subjects were divided into four areas, which were treated twice daily for one week with betamethasone, tacrolimus, emollient, or left untreated, respectively. After one week each area was challenged with a 24 h sodium lauryl sulphate patch test. The lipids were collected using the cyanoacrylate method and evaluated by high performance thin layer chromatography. For evaluation of the skin barrier, transepidermal water loss, erythema and electrical capacitance were measured. The ceramide/cholesterol ratio was increased in betamethasone- (p = 0.008) and tacrolimus-treated (p = 0.025) skin compared with emollient-treated skin. No differences in ceramide subgroups were found between treatment regimes. Pretreatment with betamethasone (p = 0.01) or with tacrolimus (p = 0.001) causes a decreased inflammatory response to sodium lauryl sulphate compared with emollient. In conclusion, treatment with betamethasone and tacrolimus has a positive effect on the ceramide/cholesterol ratio and susceptibility to irritant reaction compared with an emollient. |
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Authors:
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Jakob Mutanu Jungersted; Julie K Høgh; Lars I Hellegren; Gregor B E Jemec; Tove Agner |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 91 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-06 Completed Date: 2011-08-26 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 290-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Roskilde Hospital, University of Copenhagen, Denmark. Jungersted@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Adrenal Cortex Hormones / administration & dosage* Adult Betamethasone / administration & dosage* Ceramides / metabolism* Cholesterol / metabolism Chromatography, High Pressure Liquid Denmark Dermatitis, Irritant / metabolism, pathology, prevention & control* Electric Capacitance Emollients / administration & dosage* Erythema / metabolism, prevention & control Female Forearm Humans Immunosuppressive Agents / administration & dosage* Male Middle Aged Skin / drug effects*, metabolism, pathology Skin Irritancy Tests* Sodium Dodecyl Sulfate / administration & dosage, diagnostic use* Tacrolimus / administration & dosage* Time Factors Water Loss, Insensible Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Ceramides; 0/Emollients; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 151-21-3/Sodium Dodecyl Sulfate; 378-44-9/Betamethasone; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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