| Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice. | |
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MedLine Citation:
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PMID: 12831952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study investigated the effects of a Taiwanese yam, Dioscorea japonica Thunb var. pseudojaponica Yamamoto, on upper gut function and lipid metabolism in adult Balb/c mice. METHODS: Mice were randomly allocated to consume the control, 25%, or 50% yam diet in which yam in an uncooked lyophilized form was incorporated into the diet for 21 d. RESULTS: Growth rates were similar among groups, even though the apparent protein absorption rate was decreased by the 50% yam diet. Both yam diets decreased gastric villous width but did not significantly modulate other morphologic and proliferative indices. Brush-border leucine aminopeptidase activities in the small intestine were increased approximately 30% by the 25% and 50% yam diets, respectively. In contrast, sucrase activity was decreased 40% by the 25% yam diet and 50% by the 50% yam diet. The 50% yam diet consistently improved the cholesterol profile in the plasma and liver, whereas the 25% yam diet reduced only the level of low-density lipoprotein cholesterol in plasma. Changes in blood lipid levels were associated with reduced fat absorption. CONCLUSION: A 25% uncooked yam diet may benefit upper gut function and prevent hypercholesterolemia in humans, but the 50% yam diet negatively affected protein absorption. |
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Authors:
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Hsiao- Ling Chen; Cheng- Hsin Wang; Chen -Tien Chang; Tse- Cheng Wang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 19 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-06-30 Completed Date: 2004-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 646-51 Citation Subset: IM |
Affiliation:
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Institute of Nutritional Science, School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, People's Republic of China. hlchen@csmu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminopeptidases
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metabolism Animals Anticholesteremic Agents / pharmacology* Cell Division Cholesterol / blood, metabolism Cholesterol, Dietary / pharmacokinetics* Dietary Fats / pharmacokinetics Dietary Proteins / pharmacokinetics* Dioscorea* / chemistry Dose-Response Relationship, Drug Feces / chemistry Gastric Mucosa / cytology Intestinal Absorption Intestine, Small / enzymology Liver / metabolism Male Mice Mice, Inbred BALB C Microvilli / enzymology, metabolism Organ Size Random Allocation Sucrase / metabolism Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 0/Dietary Fats; 0/Dietary Proteins; 57-88-5/Cholesterol; EC 3.2.1.48/Sucrase; EC 3.4.11.-/Aminopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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