| Effects of TRH on hypothalamic catecholaminergic and serotoninergic neurons. | |
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MedLine Citation:
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PMID: 2886396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vivo and in vitro effects of TRH on tyrosine hydroxylase activity and on endogenous levels of noradrenaline as an index of noradrenergic neurons activity were studied in rat hypothalamus. The hydroxylation of tryptophan and the liberation of 5-hydroxyindole acetic acid were analyzed as an index of serotoninergic activity. TRH had no effect on tyrosine hydroxylase from hypothalamic homogenates in concentrations up to 100 ng/ml. Neither was the hydroxylation of tyrosine in intact hypothalamus. The TRH (4 micrograms/kg) decreased 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine accumulation after 10 min, and no effect on serotonin and noradrenaline concentrations was observed. TRH decreased endogenous levels of 5-hydroxyindole acetic acid by 35%. Thus, the results show that TRH or TSH might play a role in a short-loop feedback action involving catecholaminergic and serotonergic nerve terminals that regulate the liberation of TRH. |
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Authors:
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M Grosman; M C Rubio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: General pharmacology Volume: 18 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-09-18 Completed Date: 1987-09-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 369-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hypothalamus / drug effects* Male Norepinephrine / analysis* Rats Rats, Inbred Strains Receptors, Adrenergic / drug effects* Receptors, Serotonin / drug effects* Thyrotropin / secretion Thyrotropin-Releasing Hormone / pharmacology* Tryptophan Hydroxylase / analysis Tyrosine 3-Monooxygenase / analysis |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Serotonin; 24305-27-9/Thyrotropin-Releasing Hormone; 51-41-2/Norepinephrine; 9002-71-5/Thyrotropin; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 1.14.16.4/Tryptophan Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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