Document Detail

Effects of TRH on hypothalamic catecholaminergic and serotoninergic neurons.
MedLine Citation:
PMID:  2886396     Owner:  NLM     Status:  MEDLINE    
The in vivo and in vitro effects of TRH on tyrosine hydroxylase activity and on endogenous levels of noradrenaline as an index of noradrenergic neurons activity were studied in rat hypothalamus. The hydroxylation of tryptophan and the liberation of 5-hydroxyindole acetic acid were analyzed as an index of serotoninergic activity. TRH had no effect on tyrosine hydroxylase from hypothalamic homogenates in concentrations up to 100 ng/ml. Neither was the hydroxylation of tyrosine in intact hypothalamus. The TRH (4 micrograms/kg) decreased 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine accumulation after 10 min, and no effect on serotonin and noradrenaline concentrations was observed. TRH decreased endogenous levels of 5-hydroxyindole acetic acid by 35%. Thus, the results show that TRH or TSH might play a role in a short-loop feedback action involving catecholaminergic and serotonergic nerve terminals that regulate the liberation of TRH.
M Grosman; M C Rubio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  18     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-18     Completed Date:  1987-09-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  369-72     Citation Subset:  IM    
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MeSH Terms
Hypothalamus / drug effects*
Norepinephrine / analysis*
Rats, Inbred Strains
Receptors, Adrenergic / drug effects*
Receptors, Serotonin / drug effects*
Thyrotropin / secretion
Thyrotropin-Releasing Hormone / pharmacology*
Tryptophan Hydroxylase / analysis
Tyrosine 3-Monooxygenase / analysis
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Serotonin; 24305-27-9/Thyrotropin-Releasing Hormone; 51-41-2/Norepinephrine; 9002-71-5/Thyrotropin; EC 3-Monooxygenase; EC Hydroxylase

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