| Effects of TRH and PS-24 on colonic temperature and motor activity of rats: possible role of dopamine. | |
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MedLine Citation:
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PMID: 6794010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar to its effect in control intact rats, but PS-24 induced marked hypothermia in hypophysectomized rats. While TRH partially blocked d-amphetamine-induced hypothermia, PS-24 induced marked hypothermia in hypophysectomized rats. While TRH partially blocked d-amphetamine-induced hypothermia were blocked in olfactory tubercle-lesioned rats. The data indicate that the thermal effects of PS-24 are mediated by the dopaminergic neurons in the nucleus accumbens and are reversible by pretreatment with haloperidol in hypophysectomized rats. In addition, no correlation between the effects of the treatments on thermoregulation and motor activity was found. |
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Authors:
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S Yehuda; M B Youdim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 2 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1981 |
Date Detail:
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Created Date: 1981-12-15 Completed Date: 1981-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Dextroamphetamine / pharmacology Dopamine / physiology* Drug Synergism Haloperidol / pharmacology Hypophysectomy Male Motor Activity / drug effects* Rats Thyrotropin-Releasing Hormone / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 51-64-9/Dextroamphetamine; 52-86-8/Haloperidol; 62305-91-3/montirelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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