Document Detail

Effects of TNF-alpha injection into the ovarian parenchyma on luteal blood vessels in rabbits.
MedLine Citation:
PMID:  8822317     Owner:  NLM     Status:  MEDLINE    
It has been reported that tumor necrosis factor-alpha (TNF-alpha) derived from luteal macrophage is concerned with luteolysis. In the present study, to evaluate the correlation between TNF-alpha and regression of luteal blood vessels, recombinant human TNF-alpha (rh-TNF) was injected into the parenchyma of pseudopregnant rabbit ovaries. These injections were performed on day 7 of pseudopregnancy (functional luteal phase). Only Mg++ and Ca++ free phosphate buffer saline (PBS-) as the solvent was injected in the control group. Estimations of conditions in the luteal vessels after the injections was performed by observations of luteal vascular corrosion casts under a scanning electron microscope. Concentrations of serum progesterone before or after the injection were also assayed. In the control group, no change in the structure of luteal vessels was observed after PBS-injection, but regressing blood vessels with strictures, obstructions and rugged surfaces on the vessels were observed, and also concentrations of serum progesterone decreased noticeably after rh-TNF injection. These findings suggest that TNF-alpha plays a role in angiolysis through luteolysis in the rabbit corpus luteum.
K Nariai; K Kanayama; T Endo; A Tsukise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  42     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  761-6     Citation Subset:  IM    
Department of Veterinary Physiology, Nihon University, Kanagawa, Japan.
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MeSH Terms
Corpus Luteum / blood supply,  drug effects*
Ovary / drug effects*
Progesterone / blood
Recombinant Proteins / pharmacology
Tumor Necrosis Factor-alpha / pharmacology*
Reg. No./Substance:
0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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